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Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia

Journal of the Korean Pediatric Society 1996;39(11):1611-1619.
Published online November 15, 1996.
Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia
Yun Sil Chang1, I-Seok Kang1, Won Soon Park1, Suk Koo Lee2, Hun Hahk Kim2, Heung Jae Lee1
1Department of Pediatrics, Samsung Seoul Hospital, Seoul, Korea
2Department of Pediatric Surger, Samsung Seoul Hospital, Seoul, Korea
선천성 횡경막 탈장과 동반된 심한 폐동맥 고혈압 환아 2례에서의 Nitric Oxide가스 흡입 요법
장윤실1, 강이석1, 박원순1, 이석구2, 김현학2, 이흥재1
1삼성서울병원 소아외과
2삼성서울병원 소아외과
Abstract
Nitric oxide, an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. We have built and settled down the delivery system of nitirc oxide gas inhalation for the first time in Korea. Two newborn babies delvelped near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia. All conventional therapeutic measures failed. So we decided to attempt to use of nitric oxide gas for treatment. Addition of ntiric oxide of 1-80 parts per million to the inspired gas allowed resolution of pulmonary hypertension. No side effect of nitric oxide therapy was observed, and ventilatory support could be substantially reduced as a result of treatment and could be stopped later. On the basis of the striking and lifesaving effects of nitric oxide therapy shown in these cases, we believe that nitric oxide inhalation can be used as a major treatment modality in the management of persistent pulmonary hypertension of the newborn.
Key Words: Nitric oxide, Congenital diaphragmatic hernia, Persistent pulmonary hypertension of newborn


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