Warning: fopen(/home/virtual/pediatrics/journal/upload/ip_log/ip_log_2024-05.txt) [function.fopen]: failed to open stream: Permission denied in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 82

Warning: fwrite(): supplied argument is not a valid stream resource in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 83
The Role of Apoptosis in Adriamycin Induced Cardiotoxicity and Preventive Effect of L-carnitine in Rat

Journal of the Korean Pediatric Society 1998;41(6):760-768.
Published online June 15, 1998.
The Role of Apoptosis in Adriamycin Induced Cardiotoxicity and Preventive Effect of L-carnitine in Rat
Young Mi Hong1, Seung Sook Kim2
1Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
2Department of Pathology, College of Medicine, Ewha Womans University, Seoul, Korea
쥐에서 Adriamycin으로 유발된 심장독성에 대한 Apoptosis의 역할과 L-carnitine의 예방효과
홍영미1, 김성숙2
1이화대학교 의과대학 소아과학교실
2이화대학교 의과대학 병리학교실
Correspondence: 
Young Mi Hong, Email: 1
Abstract
Purpose
: Adriamycin is very important in cancer chemotherapy. Unfortunately, the drug shows cumulative dose dependent cardiotoxicity. The precise mechanism of this remains unclear. It has been shown that adriamycin induces programmed cell death or apoptosis in many tissues. But the role of apoptosis in adriamycin induced cardiotoxicity is uncertain.
Methods
: Sprague-Dawley rats were divided into four groups of ten animals each. All four groups were given intraperitoneal injections for 4 weeks. The first group was given 0.9% normal saline. The second group was injected twice a week with adriamycin(5mg/kg), the third group with adriamycin(5mg/kg) and L-carnitine(200mg/kg). The fourth group was injected with only L-carnitine. Cell morphology was evaluated by light and electron-microscopy. Apoptosis was detected by labelling nicked ends of DNA fragments using Tunnel staining kit.
Results
: There was no difference of the left ventricular internal dimension and ventricular septal thickness among the four groups. Apoptosis was significantly increased in the adriamycin treated group compared to the control group(P < 0.05). Addition of L-carnitine to adriamycin induced apoptosis compared significantly to apoptosis in the adriamycin only group(P < 0.05).
Conclusion
: Apoptosis may play an important role in adriamycin induced cardiomyopathy. Lcarnitine reduces adriamycin induced apoptosis.
Key Words: Adriamycin, Cardiotoxicity, L-canitine


METRICS Graph View
  • 1,982 View
  • 22 Download