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Decrease of Plasma Th2 Cytokines by Interferon(IFN) -γ Therapy in Atopic Dermatitis

Journal of the Korean Pediatric Society 1998;41(8):1128-1134.
Published online August 15, 1998.
Decrease of Plasma Th2 Cytokines by Interferon(IFN) -γ Therapy in Atopic Dermatitis
Geun Woong Noh1, Woo Gill Lee1, Dong Hee Cho2, Ki Young Lee3
1Departments of Pediatrics, Sungkyunkwan University, College of Medicine, Samsung Cheil Hospital and Women`s Healthcare Center, Seoul, Korea
2Departments of Clinical Pathology, Sungkyunkwan University, College of Medicine, Samsung Cheil Hospital and Women`s Healthcare Center, Seoul, Korea
3Departments of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
아토피 피부염에서 Interferon-γ 투여에 의한 혈중 Th2 Cytokine의 감소
노건웅1, 이우길1, 조동희2, 이기영3
1성균관대학교 의과대학 삼성제일병원 소아과
2성균관대학교 의과대학 삼성제일병원 임상병리과
3연세대학교 의과대학 소아과학교실
Correspondence: 
Geun Woong Noh, Email: 1
Abstract
Purpose
: Atopic dermatitis is characterized by reduced IFN-γ production and increased IL-4 production. As a result, IgE production increases in atopic dermatitis. In the previous studies, it was reported that recombinant IFN-γ therapy is effective in treatment of severe atopic dermatitis. In this study, changes of plasma IFN-γ, IL-4, IL-5 and IL-10 concentration by IFN-γ therapy were studied in atopic dermatitis. Changes of plasma IgE levels and eosinophil counts were also investigated in the present report.
Methods
: Sixty-five atopic dermatitis patients were studied. Diagnostic criteria for atopic dermatitis were those used by Hanifin and Rajka. Patients received 2×106 units/m2 IFN-γ by subcutaneous injection eighteen times for six weeks. The following investigations were performed : complete blood cell count, total IgE, eosinophil percentage and total eosinophil count in addition to plasma IFN-γ, IL-4, IL-5 and IL-10 concentration.
Results
: Plasma concentrations of IL-4, IL-5 and IL-10 decreased by IFN-γ therapy in atopic dermatitis. However, plasma IFN-γ concentration was not changed. No significant correlations among the changes of IgE, eosinophil counts and plasma cytokine concentrations were detected.
Conclusion
: Plasma concentrations of Th2 cytokine such as IL-4, IL-5 and IL-10 decreased by IFN-γ therapy. This study suggests that Th2 cytokines might not be produced simulaneously. and that changes of Th2 cytokines might not affect the quantitiative changes of IgE and of eosinophil count.
Key Words: Interferon(IFN)-γ, Interleukin(IL)-4, IL-5, IL-10, IgE, Atopic dermatitis, Eosinophil


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