| Usefulness of Minimal Model Analysis : Measurement of Insulin Sensitivity, Glucose Effectiveness, and Insulin Secretory Capacity from Pancreatic Islet Cells in Children with Simple Obesity or Type 2 Diabetes Mellitus |
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Se Young Kim, Sei Won Yang |
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Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
| 제2형 당뇨병 소아 및 단순 비만 소아에서 Minimal Model을 이용한 인슐린 감수성, 당유용성 및 췌도세포의 인슐린 분비능의 측정 |
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김세영, 양세원 |
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서울대학교 의과대학 소아과학교실 |
Correspondence:
Se Young Kim, Email: 1
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| Abstract |
Purpose
: It is known that insulin resistance and compensatory hyperinsulinemia from pancreatic islet cells to overcome insulin resistance could develop in children with simple obesity. When insulin resistance is aggravated by decompensation of high insulin secretion, obese children frequently progress to overt type 2 diabetes mellitus(DM). The purpose of the present study was to measure insulin sensitivity, glucose effectiveness, and insulin secretory capacity in children with simple obesity(n=15, 10.77¡¾2.62 yr) and type 2 DM(n=10, 14.22¡¾1.76yr) by frequently sampled intravenous glucose tolerance test.
Methods
: The data was analyzed as SI(insulin sensitivity), SG(glucose effectiveness) by Bergman's modified minimal model. Insulin secretory capacity was calculated as the area under the insulin curve between 0 and 19 minutes after administration of glucose(AUC, Insulin).
Results
: SI, KG, and insulin secretory capacity were significantly lower in children with type 2 DM than those in children with simple obesity(P<0.05). SG was not significantly different in both groups. There is a significant correlation between fasting glucose/insulin ratio and SI in the children with simple obesity.
Conclusion
: These results suggest that higher insulin resistance and lower insulin secretory capacity tend to progress to overt type 2 DM in obese children. Frequently sampled intravenous glucose tolerance test might be useful in predicting to progress to overt type 2 DM by serial follow up of SI in children with simple obesity. Fasting glucose/insulin can be used as a screening test to evaluate insulin resistance in children with simple obesity. |
| Key Words:
Insulin sensitivity, Glucose effectiveness, Obesity, Type 2 diabetes mellitus |
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