Warning: fopen(/home/virtual/pediatrics/journal/upload/ip_log/ip_log_2024-03.txt) [function.fopen]: failed to open stream: Permission denied in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 82

Warning: fwrite(): supplied argument is not a valid stream resource in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 83
Serum Leptin Levels in Children with Type I Diabetes Mellitus

Journal of the Korean Pediatric Society 2000;43(4):550-555.
Published online April 15, 2000.
Serum Leptin Levels in Children with Type I Diabetes Mellitus
Eun Sil Lee1, Han Ku Moon1, Yong Hoon Park1, Yong Woon Kim2
1Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea
2Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea
제 1형 당뇨병 소아에서의 혈중 Leptin 농도
이은실1, 문한구1, 박용훈1, 김용운2
1영남대학교 의과대학 소아과학교실
2영남대학교 의과대학 생리학교실
Abstract
Purpose
: Leptin is a highly hydrophobic 16-kDa protein encoded by the ob gene which is expre- ssed in adipocytes and participates in the regulation of food intake and energy expenditure. The aims of the present study were to examine the comparison of leptin levels between type I diabetes mellitus(DM) patients who received exogenous insulin therapy and healthy children, and to find out correlating factors with leptin level in type I DM.
Methods
: The study was conducted on 34 patients with type I DM and 29 healthy children. Body weight, height, leptin level and body fat percent were measured in both groups. The glycosylated hemoglobin value, C-peptide, insulin level and serum cholesterol were also measured in type I DM.
Results
: There was no statistically significant difference in mean age, sex distribution and body mass index between the experimental groups, but body fat percent in type I DM was significantly lower than that of healthy children. The mean leptin levels in male(9.4¡¾6.3ng/mL) and female(17.8¡¾10.2ng/mL) type I DM were significantly higher than in male(6.3¡¾5.7ng/mL) and female(10.2¡¾0.9ng/mL) healthy children(male : P=0.045, female : P=0.005). Serum leptin levels were strongly correlated with the body fat percent(Pearson coefficient)(r=0.712).
Conclusion
: Serum leptin level in type I DM strongly correlated with the body fat percent. Despite lowered body fat percent in type I DM, the leptin level was significantly higher than values in healthy children. The mean leptin level in type I DM were significantly higher than value in healthy children, but body fat percent of type I DM was lower than value in healthy children who were adjusted for sex, age and body mass index.
Key Words: Leptin, Insulin, Insulin-dependent diabetes mellitus, Body fat percent


METRICS Graph View
  • 2,312 View
  • 6 Download