| Outcome of Cardiac Complication in Patients of Kawasaki
Disease Treated with High-dose Gammaglobulin |
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Hyang-Sook Kim1, Jong-Tae Kim2, Ji-Yon Lee2, Jo-Won Jung2, Ki-Soo Pai2 |
1Departments of Emergency Medicine, School of Medicine, Ajou University, Suwon, Korea
2Departments of Pediatrics, School of Medicine, Ajou University, Suwon, Korea |
| 가와사끼병으로 고용량 감마글로블린 치료받은 소아에서 심장합병증의 예후에 관한 고찰 |
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김향숙1, 김종태2, 이지연2, 정조원2, 배기수2 |
1아주대학교 의과대학 응급의학과교실
2아주대학교 의과대학 소아과학교실 |
Correspondence:
Jo-Won Jung, Email: jwjung@madang.ajou.ac.kr
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| Abstract |
Purpose
: We performed the study to evaluate the risk factors associated with cardiac complication and the outcome of coronary lesions after high-dose(2g/kg, 1dose) gammaglobulin(IVIG) treatment in patients with Kawasaki disease(KD).
Methods
: Retrospective studies were performed on 338 cases of KD treated with high-dose IVIG at this hospital from May 1994 to March 1999.
Results
: Among 338 patients, fever was persistent for 8.09¡¾3.45 days in all patients and after IVIG infusion, fever subsided in 26.5¡¾26.4 hours. Forty-five patients(13.3%) with abnormal baseline echocardiogram remained febrile for 9.09¡¾4.09 days, significantly longer than normal baseline echocardiogram group. There was no significant differences in age, sex and other clinical findings. In 7 patients(2.1%) usage of medications above 12 months were needed. Eleven cases(3.3%) with persistent fever after their first course of IVIG therapy became afebrile post-second course of IVIG in 5 of the 11 cases with cardiac complication and in 1 case with recurrence. Twelve(male 11, female 1) of the 338 cases recurred after 8.45¡¾4.39 months. Three of those 12 cases had cardiac complication.
Conclusion
: The overall prevalence of persistent coronary abnormalities in KD patients treated with high-dose IVIG and aspirin remains low. Even if patients had cardiac complication, they improved later. |
| Key Words:
Kawasaki disease, High-dose gammaglobulin therapy, Cardiac complication |
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