| The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children |
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Eun Gyong Yoo, Hye Jung Shin, Duk Hi Kim |
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Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea |
| 소아연령에서 발병된 당뇨병의 병형 및 특성 |
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유은경, 신혜정, 김덕희 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children.
Methods
: We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification was based on the serum C-peptide levels, presence of ketoacidosis, autoantibodies, and insulin dependence.
Results
: Among 177 diabetic children, 147(83.1%) were classified as type 1 and 21(11.9%) as type 2, and 12(57.1%) children in type 2 were obese. All patients with age of onset before 9 were type 1. In cases of type 1, initial serum C-peptide levels were <0.6(50%), 0.6-1.0(44%) and >1.0ng/mL (6%). All patients with initial serum C-peptide level above 1.5ng/mL were type 2. Four patients initially diagnosed as type 2 DM changed to type 1 during follow-up, and 2 patients of type 1 DM changed to type 2. Only 55.4% of type 1 DM patients had insulin autoantibody, islet cell cytoplasmic antibody or anti-glutamic acid decarboxylase antibodies.
Conclusion
: Most diabetic children in Korea were classified as type 1. Our results suggest that insulin requiring lean patients with positive autoantibody should be classified as type 1 even if their serum C-peptide levels are within normal range, and the clinical types could be changed during follow-up in a small proportion of diabetic children. |
| Key Words:
Diabetes mellitus, Classification, Type 1, Type 2, C-peptide |
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