Warning: fopen(/home/virtual/pediatrics/journal/upload/ip_log/ip_log_2024-02.txt) [function.fopen]: failed to open stream: Permission denied in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 82

Warning: fwrite(): supplied argument is not a valid stream resource in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 83
Therapeutic Effect of Different Doses of Recombinant Human Granulocyte Colony-Stimulating Factor(rhG-CSF) on Neonatal Sepsis Complicated by Neutropenia

Journal of the Korean Pediatric Society 2002;45(4):439-448.
Published online April 15, 2002.
Therapeutic Effect of Different Doses of Recombinant Human Granulocyte Colony-Stimulating Factor(rhG-CSF) on Neonatal Sepsis Complicated by Neutropenia
Moon Young Choi1, Yeon Sook Jung1, Dong Woo Son2, Hyo Seop Ahn3
1Department of Pediatrics, Eulji Hospital, Seoul, Korea
2Department of Pediatrics, Bombit Hospital, Seoul, Korea
3Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
호중구 감소증이 합병된 신생아 패혈증에서 Recombinant Human Granulocyte Colony-StimulatingFactor(rhG-CSF)의 투여 용량에 따른 치료 효과
최문영1, 정연숙1, 손동우2, 안효섭3
1을지병원 소아과
2봄빛병원 소아과
3서울대학교 의과대학 소아과학교실
Correspondence: 
Moon Young Choi, Email: mrkorila@hanmail.net
Abstract
Purpose
: The aim of this study is to determine and compare the effects of adjunctive therapy with different doses of recombinant human granulocyte-colony stimulating factor(rhG-CSF) on reversing sepsis-associated neonatal neutropenia, and their survival rate in a group I/II-type trial.
Methods
: RhG-CSF was injected subcutaneously to 10 septic-neutropenic neonates with doses of 10 μg/kg from Oct. 1995 to Sep. 1996, and was administered to another 12 septic-neutropenic neonates with doses of 5 μg/kg from Oct. 1996 to Sep. 1997. Neutrophilic responses and the outcomes of both groups were compared.
Results
: In the rhG-CSF 10 μg/kg treated group and in the 5 μg/kg treated group, the absolute neutrophil count(ANC) was 1,065±89(mean±SEM) and 1,053±131, respectively. The only difference between the two groups was the peak ANC at 48 hours. Eight patients from the remaining nine of rhG-CSF 10 μg/kg treated group(88.9%) and ten in 5 μg/kg treated group(83.3%) survived the sepsis and were discharged without any problems.
Conclusion
: RhG-CSF can increase the neutrophil count in critically ill septic neutropenic neonats. The survival rate of both groups were up to 90%. This finding suggests that both doses of rhG-CSF may be effective in a therapeutically useful time frame to treat septic neonates with neonatal neutropenia attributable to bone marrow supression or neutrophil consumption.
Key Words: Neonatal sepsis, Recombinant human granulocyte colony stimulating factor Neutropenia


METRICS Graph View
  • 2,616 View
  • 6 Download