| An Epidemiologic Study of Kawasaki Disease(1987-2000) :
Incidence of Coronary Artery Complication in the Acute Stage |
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Kyung-Yil Lee, Min-Young Park, Ji-Whan Han, Hyung-Shin Lee, Jin Choi, Kyung-Tai Whang |
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Department of Pediatric, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| 가와사끼병의 역학적 연구(1987-2000년) :관상 동맥 이상을 중심으로 |
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이경일, 박민영, 한지환, 이형신, 최진, 황경태 |
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가톨릭대학교 의과대학 소아과학교실 |
Correspondence:
Kyung-Yil Lee, Email: leekyungyil@yahoo.com
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| Abstract |
Purpose
: We evaluated the epidemiologic characteristics and incidence of coronary artery sequele of children with KD according to treatment.
Methods
: We retrospectively analyzed 506 medical records of children with KD, who were admitted at Daejeon St. Mary's Hospital from Jan. 1987 to Dec. 2000.
Results
: The mean annual incidence was 36.1±11.1 cases per year. There was a slightly higher occurrence in summer with no significant difference in monthly incidence. The mean age was 2.4＋1.7 years and 450 children(88.9%) were below four years of age. The male to female ratio was 1.7 : 1. When the 345 cases between 1987 and 1994 were divided into three groups according to treatment, incidences of the coronary abnormality(above grade II) of aspirin-treated(54 cases; 15.6%), divided-intravenous immunoglobulin(IVIG) treated(400-500 mg/day×4-5 days, 224 cases; 64.9%), and one-dose IVIG treated(2.0 g/day, 67 cases; 19.5%) groups were 8.3%, 6.0%, and 7.5%, respectively. Between 1995 and 2000, 143 cases were treated with only one-dose IVIG and 21 cases(14.7%) showed coronary artery abnormalities(grade I, 15 cases; grade II, two cases; and grade III, four cases). Among the 143 cases, 22 cases(15.1%) were retreated with IVIG and/or steroid pulse therapy. The incidence of coronary artery abnormality in this group was 50.0%. Incidences of cases in recurrence and among siblings were 0.6% and 0.4% respectively. There was no fatal case.
Conclusion
: In Daejeon, Korea, the epidemiologic feature of KD showed slight annual variations without monthly differences. The incidence of coronary abnormality with one-dose IVIG therapy was 14.7%. The nonresponse of this therapy was 15.1% with a coronary abnormality of 50.0%.
Conclusion
: In Daejeon, Korea, the epidemiologic feature of KD showed slight annual variations without monthly differences. The incidence of coronary abnormality with one-dose IVIG therapy was 14.7%. The nonresponse of this therapy was 15.1% with a coronary abnormality of 50.0%. |
| Key Words:
Kawasaki disease, Epidemiology, Coronary artery, Complication |
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