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Maternal and Neonatal Outcome of Twin Pregnancies after in vitro Fertilization and Embryo Transfer

Journal of the Korean Pediatric Society 2003;46(3):224-229.
Published online March 15, 2003.
Maternal and Neonatal Outcome of Twin Pregnancies after in vitro Fertilization and Embryo Transfer
Kyung-Ah Kim1, Uoo-Gyung Min2, Jae-Woo Lim2, Nu-Lee Jun2, Hye-Sung Won3, Chung-Hoon Kim3, Ellen Ai-Rhan Kim2, Pil-Ryang Lee3, In-Sik Lee3, Ki-Soo Kim2, Ahm Kim3, Soo-Young Pi2
1Department of Pediatrics, Samsung Jeil Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea
2Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea
3Division of Neonatology, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea
체외수정시술로 출생한 쌍생아의 임상적 경과에 대한 비교 분석
김경아1, 민우경2, 임재우2, 전누리2, 원혜성3, 김정훈3, 김애란2, 이필량3, 이인식3, 김기수2, 김암3, 피수영2
1성균관대학교 의과대학 삼성제일병원 소아과
2울산대학교 의과대학 서울아산병원 소아과
3울산대학교 의과대학 서울아산병원 산부인과
Correspondence: 
Ellen Ai-Rhan Kim, Email: arkim@amc.seoul.kr
Abstract
Purpose
: To examine various neonatal outcomes and perinatal factors resulting from assisted reproduction compared to that of spontaneous conception.
Methods
: This is a retrospective study. The control cases were all twins of spontaneous conception born between periods from January 1995 to June 2000. The study cases were identified from twins conceived by assisted reproduction in the same time peried. A total of 460 sets of twins consisted of 250 twins of spontaneous conception and 156 twins of assisted reproduction were studied. The primary outcomes were neonatal morbidity and mortality and the secondary outcomes were perinatal factors including number, length and cost of hospitalization for the delivery.
Results
: No differences were seen in various neonatal factors including gestational age, birth weight and incidences of respiratory distress syndrome, patent ductus arteriosus, necrotizing enterocolitis, hyperbilirubinemia, sepsis, intraventricular hemorrhage and the length of hospitalizations. Lower one minute and five minute Apgar scores and frequently encountered electrolyte abnormalities were observed in neonates of assisted reproduction. In general, the second twin of assisted reproduction had increased incidences of respiratory distress syndrome, sepsis and necrotizing enterocolitis than the first twin. Increased frequencies of preterm labor, hospitalization and elective cesarean section were seen among mothers who underwent artifical conception. However, overall hospital costs in terms of mothers hospitalization for the delivery and neonates hospitalization did not show differences.
Conclusion
: Assisted reproduction twins had similar neonatal morbidities, mortalities and perinatal morbidities compared to those born by spontaneous conception.
Key Words: In vitro fertilization and embryo transfer, Twin pregnancy, Neonatal outcome


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