| Study on the Correlation between Clinical Classification according to Hemorrhagic Symptoms and Platelet Counts in Childhood Idiopathic Thrombocytopenic Purpura |
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Ho Il Bang1, Sae Ron Shin2, Du Young Choi1 |
1Department of Pediatrics, Wonkwang University School of Medicine, Iksan, Korea
2Department of Family Medicine, Jeon Ju Hospital, Jeon Ju, Korea |
| 소아 특발성 혈소판 감소증에서 출혈 증상에 따른 임상적 분류와 혈소판 수치와의 상관성에 관한 연구 |
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방호일1, 신새론2, 최두영1 |
1원광대학교 의과대학 소아과학교실
2전주병원 가정의학과 |
Correspondence:
Du Young Choi, Email: cdy8118@wonkwang.ac.kr
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| Abstract |
Purpose
: Idiopathic thrombocytopenic purpura(ITP) is a relatively common hematologic disease in children. The optimal strategy for treating ITP during childhood is a matter of controversy. In general, platelet count has been the primary, if not the sole measure, on which treatment decisions have been made and outcomes determined. In this study, we tried to find out the correlation between clinical classification of Bolton-Maggs and platelet counts in childhood ITP on initial diagnosis
Methods
: Seventy three patients with acute ITP in the Department of Pediatrics, Wonkwang University Hospital from June 1995 to December 2002, were enrolled. We retrospectively analyzed charts and classified our patients into four groups(no, mild, moderate, severe symptoms) according to Bolton-Maggs criteria.
Results
: The ratio of female to male is 0.82. The peak age incidence was two to five years(41%). It was prevalent in the spring in 23 cases(31%) and winter season in 23 cases(31%). Most common clinical symptoms at presentation were petechiae and purpura in 55 cases(75.1%). According to Bolton-Maggs criteria, our patients, classified into no symptoms, mild symptoms, moderate symptoms and severe symptoms were 9 cases(12%), 22 cases(29%), 23 cases(30%) and 19 cases(25%), respectively. Among the 47 patients with platelet counts below 20,000/mm3, those with no symptoms, mild symptoms, moderate symptoms and severe symptoms were : 1 cases(0.02%), 13 cases(27%), 17 cases (36%) and 16 cases(34%) respectively. We found that this classification was highly correlated with the platelet counts on initial diagnosis(P=0.005).
Conclusion
: There was a significant correlation between clinical classification of Bolton-Maggs and platelet counts. Therefore, this classification may be helpful in choosing the appropriate treatment options and evaluating the overall outcomes in childhood ITP. |
| Key Words:
Idiopathic thrombocytopenic purpura, Clinical classification |
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