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Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia

Korean Journal of Pediatrics 2004;47(5):527-531.
Published online May 15, 2004.
Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia
In Sook Yang, Jung Hyun Lee, Hyung Shin Lee, So Young Kim, Sung Dong Choi, In Kyung Sung, Chung Sik Chun
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
Insulin-like Growth Factor-I 및 1,25-(OH)2 Vitamin D3 농도가 임신성 고혈압 모체로부터 출생한 신생아의 자궁 내 발육에 미치는 영향
양인숙, 이정현, 이형신, 김소영, 최성동, 성인경, 전정식
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
In Kyung Sung, Email: sinky@catholic.ac.kr
Abstract
Purpose
: This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia.
Methods
: Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and their newborns(normotensive group) were observed. IGF-I and 1,25-(OH)2 Vit. D3 concentrations in maternal and umbilical cord blood were analysed.
Results
: Maternal and umbilical cord blood levels of IGF-I and 1,25-(OH)2 Vit. D3 were significantly lower in the preeclampsia group than in the normotensive group. In the preeclampsia group, maternal and cord blood levels of IGF-I of small-for-gestational age newborns were significantly lower than those of appropriate-for-gestational age newborns. The birth weight and length of newborns correlated with IGF-I concentrations of maternal and umbilical cord blood in small-for-gestational age newborns of preeclampsia group. The correlation between IGF-I and 1,25-(OH)2 Vit. D3 was significant in the umbilical cord blood of preeclampsia group, but only in appropriate-for-gestational age newborns.
Conclusion
: It is suggested that the lower level of IGF-I is the primary factor of intrauterine growth retardation in preeclampsia, and the effect of IGF-I on the metabolism of 1,25-(OH)2 Vit. D3 is different according to the presence of preeclampsia and intrauterine fetal growth retardation.
Key Words: Preeclampsia, IGF-I, 1,25-(OH)2 vitamin D3, Intrauterine growth retardation


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