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Update on treatment in acute stage of Kawasaki disease

Korean Journal of Pediatrics 2008;51(5):457-461.
Published online May 15, 2008.
Update on treatment in acute stage of Kawasaki disease
Ji Whan Han
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
가와사끼병 급성기 치료의 최신 지견
한지환
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
Ji Whan Han, Email: han59@catholic.ac.kr
Abstract
Kawasaki disease (KD) was first described by Dr. Tomisaku Kawasaki in his 1975 study, published in Pediatrics. Its pathogenesis is still not clearly understood. Early diagnosis and treatment are very important to preventing concomitant coronary artery complications. Most KD patients respond well to the standard treatment of aspirin and intravenous immunoglobulin; however, some of them are refractory to the standard treatment, and so adjuvant therapies with corticosteroids and anti-tumor necrosis factor-α (TNF-α) antibody are necessary. In this article, the author reviews and summarizes the most recent literature on the treatment of refractory KD.
Key Words: Refractory Kawasaki disease, Adjuvant therapy


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