| Clinical course and prognosis of hemodynamically significant congenital heart defects in very low birth weight infants |
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Hye Soo Yoo1, Ji Eun Kim1, Soo Kyoung Park1, Hyun Ju Seo1, Yoo Jin Jeong1, Seo Heui Chio1, Soo In Jeong1, Sung Hoon Kim1, Ji Hyuk Yang2, June Huh1, Yun Sil Chang1, Tae Gook Jun2, I Seok Kang1, Won Soon Park1, Pyo Won Park2, Heung Jae Lee1 |
1Department of pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
1Department of pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of thoracic and cardiovascular surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
| 혈역학적으로 의미있는 선천성 심기형을 가진 극소 저체중 출생아의 임상경과 및 예후 |
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유혜수1, 김지은1, 박수경1, 서현주1, 정유진1, 최서희1, 정수인1, 김성훈1, 양지혁2, 허 준1, 장윤실1, 전태국2, 강이석1, 박원순1, 박표원2, 이흥재1 |
1성균관대학교 의과대학 삼성서울병원 소아과학교실
1성균관대학교 의과대학 삼성서울병원 소아과학교실
2성균관대학교 의과대학 삼성서울병원 흉부외과학교실 |
Correspondence:
Won Soon Park, Email: wonspark@skku.edu
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| Abstract |
Purpose
: This study investigated the clinical course and prognostic factor of very low birth weight infants (VLBWI) with hemodynamically significant congenital heart defects (CHDs).
Methods
: Medical records of 1,098 VLBWI with birth weight <1,500 g who had been admitted to the neonatal intensive care unit of Samsung Medical Center from October 1994 to December 2007 were reviewed retrospectively. The data for these patients with hemodynamically significant CHD (n=33) were compared with those without CHD (n=1,065).
Results
: The incidence of CHD was 3.0% (33 patients) 7 patients (21%) had CHD combined with the congenital abnormalities or chromosomal disorders. The most common CHD was a ventricular septal defect. The incidence of intrauterine growth retardation was higher in patients with CHD than in patients without CHD (34% vs. 20%), but there were no significant differences in gestational age, birth weight, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, severe intraventricular hemorrhage (≥Gr III), and periventricular leukomalacia. Cardiac surgery was performed on 13 patients (39%). Nine patients received staged operations, and 10 patients received early intervention. The overall mortality in patients who had CHD was higher than in the patients who did not have CHD (27% vs. 16%). In patients with CHD, congenital abnormalities or chromosomal disorders were more important factors for increased mortality (86% vs. 11%) than the degree of complexity of CHD (19% vs. 42%).
Conclusion
: The most important prognostic factors of VLBWI with CHD are the associated congenital abnormalities or chromosomal disorders. |
| Key Words:
Infant, Very Low Birth Weight, Congenital Heart Defects, Congenital Abnormalities, Chromosome Disorders |
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