| A case of the lupus syndrome induced by hydralazine. |
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Beom Soo Park, Joong Gon Kim, Yong Soo Yun |
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Department of Pediatrics, Seoul National University Collage of Medicine, Seoul, Korea |
| Hydralazine에 의하여 유발된 Lupus Syndrome 1례 |
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박범수, 김중곤, 윤용수 |
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서울대학교 의과대학 소아과학교실 |
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Received: 28 September 1990 • Accepted: 29 November 1990 |
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| Abstract |
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A reversible syndrome resembling systemic lupus erythematosus is induced by hydralazine which
has been used in treatment of hypertension or congestive heart failure. The incidence of the lupus
syndrome induced by hydralazine was estimated at 6.8% in adults (Cameron, 1984) but there was few
reports in children.
A 9 year old girl had arthralgia, fever, splenomegaly, pleurisy and oral ulcer after 62 months of
hydralazine therapy《3〜4 mg/kg/day) for congestive heart failure due to dilated cardiomyopathy.
Laboratory work ups showed positive fluorescent antinuclear antibody (FANA), positive LE cell,
pancytopenia, decreased level of C4 and CH50, positive anti-ds DNA antibody, proteinuria and
hematuria. Clinical symptoms and laboratory abnormalities returned to normal after steroid therapy
with discontinuing the hydralazine therapy.
We report a case of the lupus syndrome induced by hydralazine in a child who had suffered form
congestive heart failure due to dilaged cardiomyopathy with a brief review of literatures. |
| Key Words:
Hydralazine, Lupus syndrome |
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