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Bone Marrow Cell Culture(GM-CFU) in Anaplastic Anemia of Children.

Journal of the Korean Pediatric Society 1985;28(9):888-898.
Published online September 30, 1985.
Bone Marrow Cell Culture(GM-CFU) in Anaplastic Anemia of Children.
Jae Sun Jung, Chang Yee Hong
Department of Pediatrics,College of Medicine, Seoul National University
再生不良性 貧血 患兒의 骨髓幹細胞 集落形成 (GM-CFU) 과 豫後와의 關係
鄭在善, 洪影義
서울大學校 醫科大學 小兒科學敎室
Bone marrow cell cultures (GM-CFU) were performed in the 15 cases of children with aplastic anemia and the correlation with the clinical course were investigated. They have been treated with androgen with or without low dose prednisone and supportive care. Bone marrow cell cultures from 8 children without any evidence of aplastic anemia were performed as a control. 1)In control group, colonies were 26 to 57, mean 40.50±13.58. 2)In the patients of aplastic anemia, colonies were 0 to 28, mean 5.74±9.06 (p<0.001). 3) In 15 cases of aplastic anemia, 2 were died within 6 months after the diagnosis. Their bone marrow cell cultures revealed 0 colony and 0 cluster. Their Lynch indeces at the time of diagnosis were high, above 0.041. The other 13 patients are still alive(6 months to 121 months). Four of them are in complete remission, and their Lynch indeces were much lower. The percentage of nonmyeloid cells in bone marrow was inversely correlated with the clinical course. 4)Initial grading of severity according to the peripheral blood findings was not well correlated with the clinical course (sensitivity 50%). The patients who revealed one or more colonies on their bone marrow cell culture showed favorable clinical course (sensitivity 88%). In predicting the clinical course of the aplastic anemia,the result of the bone marrow cell culture would be useful in addition to the findings of the peripheral blood and bone marrow cellularity.
Key Words: Aplastic anemia, Bone marrow cell culture(GM-CFU)

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