Journal of the Korean Pediatric Society 1985;28(4):330-339.
Published online April 30, 1985.
The Use of Pedialyte(R) RS(oral electrolyte solution) and Isomil(R) in the Treatment of Nonbacterial Acute Infantile Gastroenteritis.
Keun Soo Lee, Seung Jae Yang, Soo Jee Moon, Hahng Lee
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
영유아 설사 환아에서 경 구 전해질 용액 (Pedialyte® RS)과 Lactose free formula (Isomil®)의 치료효과에 관한 임상적 고찰
이근수, 양승재, 문수지, 이 항
한양대학교 의과대학 소아과학교실
40 Pediatric patients with mild to moderate dehydration due to nonbacterial acute infantile gastroenteritis were admitted to the study. On admission to the hospital, each patient was assigned at random either to the Pedialyte® RS+Isomil®(Group A), or to intravenous fluid+cow's milk-based formula (Group B). Each group consisted of 20 patients. There were no significant differences between the two group as for body weight, age, sex ratio, duration of diarrhea, number of stools per day, degree of dehydration, serum Na contentration, BUN, and CO2 content perior to treatment, as seen in Tables 2-1, 2-2, 3 and 4. Initial management of dehydration due to diarrhea for Group A was oral administration of Pedialyte® RS and that for Group B was IV. fluid therapy. From 2nd or 3rd day 1/2 strength Isomil® to Group A and 1/2 strength cow’s milk-based formula to Group B were given. The following results were obtained from this clinical study. In Group A 18 patients successfully responded and 2 failed. In Group B 13 patients successfully responded and 7 failed. None in Group A required IV fluid therapy. As shown in Table 5, the number of stools passed per day did not differ significantly in the two groups. However, as shown in Table 7 a difference (17 to 12) was noted in the number of patients who passed normal stools or who had no stool after 2 days of treatment. From this study, the authors conclude that the use of oral Pedialyte® RS and subsequent administration of Isomil® seems as effective as or even preferable to IV fluid therapy and subsequent administration of cow's milk-based formula for the treatment of mild to moderate dehydration due to nonbacterial acute infantile gastroenteritis.
Key Words: Nonbacterial acute infantile gastroenteritis, Pedialyte® RS (oral electrolyte solution), Isomil®

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