| A Clinical Study of Reye`s Syndrome. |
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Young Seo Park, Hwan Jong Lee, Sang Pok Suk, Jeong Kee Seo, Kwang Wook Ko |
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Dept, of Pediatrics，College of Medicine，Seoul National University |
| Reye증후군에 대한 임상적 고찰 |
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박영서, 이환종, 석상복, 서정기, 고광욱 |
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서울대학교 의과대학 소아과학교실 |
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| Abstract |
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Seventy-four cases of Reye’s syndrome, diagnosed during the period of 1978-1983 at the
Pediatric ward of Seoul National University Hospital, were studied on the clinical features
and laboratory findings.
The following results were obtained;
1) The annual incidence was increasing year by year and the monthly incidence was highest in September.
2) The sex ratio of male to female was 1.2:1. The highest incidence was showed between 7 and 12 months of age, and most of cases(73%) were under the 2 years of age. 3) The prodromal illness was present in 89% of cases.
4) The main clinical symptoms were disturbed consciousness(100%), vomiting(54%). fever (54%), hyperpnea(54%), seizure (53%) and diarrhea(6%). The hepatomegaly was noticed in
41% of cases and the mild jaundice was noticed in 6% of cases.
5) According to Lovejoy’s classification, the majority of cases were in stage H or above on admission (64%).
The higher the stage, the higher the mortality.
6) The mortality was high in patients with the following laboratory findings.
a) GOT≧300U/L
b) LDH≧500 IU/L
c) Ammonia>300 microgm/dl
7) The average mortality was 53%.
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| Key Words:
Reye’s Syndrome.
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