| Developmental Changes of Membrane Proteins from Human Erythrocytes. |
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Chan Uhng Joo1, Hyun Suk Lee1, Jung Soo Kim1, Kyu Cha Kim1, Hyung Rho Kim2 |
1Department of Pediatrics, Jeonbug National University Medical School, Korea.
2Department of Biochemistry, Jeonbug National University Medical School, Korea. |
| 성장에 따른 인체 적혈구막 단백의 변화 |
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주찬응1, 이현숙1, 김정수1, 김규차1, 김형로2 |
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 생화학교실 |
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| Abstract |
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To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and glucose transport systems. 1. Adult and fetal erythrocyte membranes appeared to have the same major proteins and gl-ycoproteins in the electrophoretic pattern. 2. ATPase activity in adult erythrocyte membranes was lower than that of fetal erythrocyte membranes, whereas adult cholinesterase was higher. No significant change was observed in the activities of alkaline and acid phosphatases during development. 3. Glucose uptake was higher in fetal erythrocytes than in adult erythrocytes, suggesting some loss of glucose carrier system during devlopment. The results suggest that the major structural proteins in human erythrocyte membrane relatively unchanged while some functional proteins such as membrane enzymes and carrier proteins in transport systems are markedly changed during development. |
| Key Words:
Membrane Proteins, Human Erythrocytes |
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