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Lupus Nephritis: 2 cases report and literature review.

Journal of the Korean Pediatric Society 1979;22(7):538-545.
Published online July 15, 1979.
Lupus Nephritis: 2 cases report and literature review.
Hong Kyu Lee1, Young Mo Sohn1, Soo Hyung Kim1, Ki Sub Chung1, Phung Kil Kim1, Duk Jin Yun1, Tai Seung Kim2, In Joon Choi2
1Department of Pediarics, Yonsei University College of Medicine Seoul, Korea.
2Deparment of Pathology, Yonsei University College of Medicine Seoul, Korea.
Lupus Nepritis 2 예
이홍규1, 손영모1, 김수형1, 정기섭1, 김병길1, 윤덕진1, 김태승2, 최인준2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 병리학교실
Lupus nephritis is one of complication of systemic lupus erythematous involving many organ systems. And the incidence of renal involvement is about 80%. Principal site of renal injury is glomerulus, and immune complex and complements are deposited in mesangium, basement membrane capillary loops of the glomerulus in lupus nephritis. Histopathologically, 4 distinct forms of renal injury may be seen such as minimal form, focal segnemtal proliforative form, membranous form and diffuse proliferative form. The treatment of lupus nephritis requires steroid and immunosuppresive drugs, but the prognosis varies according to the types of renal lesion, and the time of therapy. Recently we had the opportunity to observe 2 cases of lupus nephritis at this hospital whose clinical and histopathological features were consistent with criteria criteria for the disease. Inspite of conservative treatment and steroid therapy, one case died, the other was discharged in grave condition.

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