| Study on the Effect of Phototherapy on Neonatal Jaundice |
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Sun Hee Lee |
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Department of Pediatrics, College of Medicine Yonsei University |
| 초생아 황달의 광선조사 치료효과에 관한 연구 |
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이선희 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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In 1958, Cremer had demonstrated that serum ibilirubin concentration of new born infant can be reduced by exposure to light. There were manyVeports about the effect of phototherapy on hyperbilirubinemia and premature baby. A controlled clinical trial has been carried out among 48 full term infant who were selected by
random sampling to test the effectiveness of artificial 300 foot candle white fluorescent light in normal physiologic jaundice. ^Twenty four (Male jll, Femal 13) control group and 24 (Male 11,Female 13) phototherapy group were divided alternately. Infant in phototherapy group were exposed to light (Apart with the light source about 100 cm above the infant) starting in the first 24 hours of life, usually in the first 8 hours and continued for 3 days except feeding time and parent visiting time which may be mounted to 5 or 6 hours a day. The infant were unclothed except for a eye cover and diaper. Infant in the control group were managed in the same manner, except exposure to "light. All infants with pathologic conditions were excluded. Blood samples were collected in
Natelson microblood collecting tubes by heel puncture daily using the tip of a No. 11 blade. Approximately 0.1 ml to 0. 2 ml of serum was obtained and bilirubin level determined by the method of Hsia and Associates.
The following results were obtained.； The bilirubin levels of the cord blood shows no significant difference between two groups and its average is 0. 8 mg/dl. The serum bilirubin levels of the phototherapy group is 4. 050±0. 362 mg/dl on DayJl, 6. 591 ±0. 366 mg/dl on Day 2, 7. 0±0. 844 mg /dl on Day 3. The serum bilirubin levels of the control group is 5. 720±0. 442 on Day 1, 7. 608 土0. 421 mg/dl on Day 2, 9.164土0.335 mg/dl on Day 3. (Listed, on Table 3). The mean serum bilirubin values of the phototherapy grouplwere lower than those of the control group 0. 870 mg/dl on Day 1, 1. 007 mg/dl ;on Day 2, 2.164 mg/dl on Day 3. 1)The rise in Bilimbin over the base level in phototherapy group was 4. 033±0. 424 mg/dl on Day 1, 5. 595+0. 378 mg/dl on Day 2} and 7.123+0. 428 mg/dl on Day 3. (Listed on table 5). 2)The rise in bilirubin over the base level of thephototherapy group were significantly lower than control group*on Day 1 (P value<0. 025), on Day 2 (P vaIue<0.1), and on Day 3 (P value<0. 025).
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