| Clinical Observation of Aplastic Anemia |
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Ja Hwan Kim, Bo Kyung Kim, Yee Ja Kim, Young Un Moon, Duk Jin Yun |
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Department of Pediatrics,Yonsei University, College of Medicine |
| 再生不能性 貧血의 臨床的 觀察 |
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金慈換, 金寶聊, 金義子, 文永殷, 尹德鎭 |
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延世大學校 醫科大學 小兒科學敎室 |
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| Abstract |
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This paper deals with a group of 22 patients diagnosed at Severance Hospital between 1959 and 1965 as having aplastic anemia. Age incidence in the group of patients was 7 to 14 years except for one case. There was a striking difference in sex incidence, 16 cases were in males and 6 cases in females. The chief complaints in 16 patients at admission were severe hemorrhage, purpure, and anemia. The periperal blood was characterized by a pancytopenia, macrocytic, and normocytic in some patients. Coomb’s test was done in 6 of the 22 patients, none of whom showed positive findings. Bone marrow showed hypocellularity (less than 20 per cent of the normal cellularity) and fatty infiltration. The underlying causes of marrow insufficiency in 19 patients was not precisely defined, but Chinese drugs were suspected as causative agents in patients. In 2 patients Chinese drugs and Chlorampenicol were suspected. Chlorampenicol was definitely the causative agent in 3 patients. All the aplastic anemia patients were treated with tranfusion of blood, and corticosteroid combined with tespsterone. Fifteen of the patients ultimately died. Seven childrens are still living, 2 of them are recovered completely, four patients are clinically improved. One patient shows no response to treatment.
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