Article Contents
Clin Exp Pediatr > Volume 68(3); 2025 |
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Acknowledgments
Part of this work was accepted for a poster presentation at the European Calcified Tissue Society Meeting 2024 in Marseille, France, 25-28 May 2024. We extend our gratitude to the patients and their families for their participation in this study. We also acknowledge the support of the Khon Kaen University Faculty of Medicine and the Mekong Health Science Research Institute Biobank Project.
Values are presented as mean±standard deviation, number (%), or median (interquartile range).
21OHD, 21-hydroxylase deficiency; SW, salt-wasting; SV, simple virilizing; GC, glucocorticoid; BMI, body mass index; 17OHP, 17-hydroxyprogesterone; 25OHD, total 25-hydroxyvitamin D2/D3; OC, osteocalcin; CTX, C-terminal telopeptide of type-I collagen; LSBMD, lumbar spine bone mineral density; TBS, trabecular bone score.
Boldface indicates a statistically significant difference with P<0.05.
Values are presented as mean±standard deviation, median (interquartile range), or number (%).
DXA, dual-energy x-ray absorptiometry; GC, glucocorticoid; 17OHP, 17-hydroxyprogesterone; 25OHD, total 25-hydroxyvitamin D2/D3; %ΔLSBMD/yr, annual percentage change in lumbar spine bone mineral density; TBS, trabecular bone score; %ΔTBS/yr, annual percentage change in TBS.
Boldface indicates a statistically significant difference with P<0.05.
Variable | Baseline TBS z score | %∆TBS/yr |
---|---|---|
Baseline | ||
Age | 0.182 | -0.375a) |
Bone age | 0.271 | -0.333a) |
Simple virilizing subtype | 0.093 | 0.119 |
Height z score | -0.279 | 0.271 |
BMI percentile | 0.661c) | -0.433a) |
Tanner stage | 0.032 | -0.398a) |
Daily GC dose | -0.003 | -0.022 |
LSBMD z score | 0.489b) | -0.233 |
OC z score | 0.050 | 0.111 |
CTX z score | 0.016 | 0.192 |
25OHD | 0.023 | - |
17OHP | 0.134 | - |
Testosterone | 0.337* | - |
Follow-up | ||
Average 17OHP | - | -0.379 |
Average testosterone | - | -0.145 |
Average 25OHD | - | -0.153 |
Average daily GC dose | - | -0.061 |
Cumulative GC dose | - | -0.008 |
%∆LSBMD/yr | - | 0.309 |
TBS, trabecular bone score; %ΔTBS/yr, annual percentage change in TBS; BMI, body mass index; GC, glucocorticoid; LSBMD, lumbar spine bone mineral density; OC, osteocalcin; CTX, C-terminal telopeptide of type-I collagen; 25OHD, total 25-hydroxyviatmin D2/D3; 17OHP, 17-hydroxyprogesterone; %ΔLSBMD/yr, annual percentage change in LSBMD.