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Original Article
Economic evaluation of a weekly administration of a sustained-release injection of recombinant human growth hormone for the treatment of children with growth hormone deficiency
Hye-Young Kang, Duk Hee Kim, Sei-Won Yang, Yoon-Nam Kim, Miseon Kim
Clin Exp Pediatr. 2009;52(11):1249-1259.   Published online November 15, 2009
Purpose : From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency. Methods : Health-related utility for GH therapy was measured based on the visual analogue scale. During July...
The effect of Lantus on glycemic control in children and adolescents with type 1 diabetes mellitus
Young Jun Rhie, Hyun Wook Chae, Ho Seong Kim, Duk Hee Kim
Clin Exp Pediatr. 2007;50(6):565-569.   Published online June 15, 2007
Purpose : With a duration of action of approximately 24 hours and peakless levels, Lantus is a more physiologic basal insulin analogue compared with NPH. The aim of this study was to compare the glycemic control of Lantus plus Humalog with that of premixed insulin in children and adolescents with type 1 diabetes mellitus. Methods : The subjects consisted of...
The effect of growth hormone treatment in short children born small for their gestational ages
Joo Hee Seo, Duk Hee Kim
Clin Exp Pediatr. 2006;49(3):312-316.   Published online March 15, 2006
Purpose : Growth hormone(GH) has been recognized as an effective treatment for short children born small for their gestational ages(SGA), and nowadays it has been widely used for the treatment of short children born SGA. The aim of this study is to assess the efficacy of GH treatment for the children born SGA. Methods : The study population was made of...
Serum Ferritin as a Risk Factor in Type 2 Diabetes Mellitus
Jung Hyun Kim, Ho Seong Kim, Duk Hee Kim
Clin Exp Pediatr. 2005;48(11):1239-1243.   Published online November 15, 2005
Purpose : Iron accumulation interferes with hepatic insulin extraction and affects insulin synthesis and secretion. The purpose of this study is to investigate the correlation between serum ferritin and type 2 diabetes mellitus. Methods : We compared the serum ferritin level among 18 patients in an impaired glucose tolerance (IGT) group, 36 in a type 1 diabetes group, eight in...
Affecting Factors of Insulin Resistance in Obese Children and Adolescents
Duk Hee Kim, Ho Seon Eun, In Kyung Choi, Ho Seung Kim, Bong Soo Cha, Dong Kee Kim
Clin Exp Pediatr. 2005;48(10):1076-1081.   Published online October 15, 2005
Purpose : Insulin resistance is the most important risk factor linked to the development of impaired glucose tolerance(IGT), diabetes mellitus and cardiovascular diseases in childhood and adolescent obesity, The purpose of this study was to see whether insulin resistance of obese adolescent is higher than that of obese children. and to analyze gender difference and affecting factors of insulin resistance. Methods...
Prevalence of the Nonalcoholic Fatty Liver Disease in Obese Children
Sung Woog Hwang, Duk Hee Kim, Ho Seong Kim
Clin Exp Pediatr. 2005;48(1):13-20.   Published online January 15, 2005
Purpose : Obesity is, along with metabolic syndrome, closely related with nonalcoholic fatty liver disease. This study tried to evaluate the prevalence of nonalcoholic liver disease in obese children and verify the factors associated with the disease. Methods : Two hundred and seventy nine children who showed a body mass index of 95 percentile over the baseline in health examinations...
Prevalence of Metabolic Syndrome in Obese Children
Jin Ha Chang, Duk Hee Kim, Ho-Seong Kim, In Kyoung Choi, My Young Cheong, Dong Kee Kim
Clin Exp Pediatr. 2004;47(11):1149-1156.   Published online November 15, 2004
Purpose : Obesity has been known to be a cause of insulin resistance and dyslipidemia, and along with coronary artery disease and diabetes, is associated with metabolic syndrome(MS). This study aimed to ascertain the cause and prevalence of MS in obese children and adolescents. Methods : Two hundred and seventy-seven school children, who showed more than a 95th percentile of body...
The Prevalence of Maturity Onset Diabetes of the Young(MODY) 3 in Children with Type 2 Diabetes Mellitus
In Kyoung Choi, Duk Hee Kim, Ho-Seong Kim, Nam Huh, Sang Hyun Paek, Seoung Young Jung
Clin Exp Pediatr. 2004;47(6):641-646.   Published online June 15, 2004
Purpose : Maturity-onset diabetes of the young(MODY) is a subtype of type 2 diabetes defined by autosomal dominant mode of inheritance, onset of diabetes usually before the age of 25 yrs, and a primary defect in the function of the beta cells of the pancreas. MODY3 is known as the most common form and is caused by mutations in hepatocyte...
The Effect of Growth Hormone on Patients with Growth Hormone Deficiency and Idiopathic Short Stature
Jeong Cheol Kang, Yoon Suk Choi, In Kyong Choi, Ho Sung Kim, Duk Hee Kim
Clin Exp Pediatr. 2004;47(3):310-318.   Published online March 15, 2004
Purpose : This study was designed to evaluate the effect of growth hormones on children with growth hormone deficiency(GHD) or idiopathic short stature(ISS). Methods : Between January 1988 to July 2003, 45 patients(M26, F19) with GHD and 24 patients (M13, F11) with ISS were enrolled in this study. Height standard deviation score(Ht SDS) for chronological age(CA) and Ht SDS for bone...
Autonomic Neuropathy in Adolescents with Diabetes Mellitus
Eun-Gyong Yoo, Sun-Young Ahn, Duk Hee Kim
Clin Exp Pediatr. 2003;46(6):585-590.   Published online June 15, 2003
Purpose : This study is designed to determine the prevalence of cardiovascular autonomic neuropathy and its relationship to risk factors in adolescents with diabetes mellitus(DM). Methods : Ninety-two diabetic patients(80 with type 1 DM and 12 with type 2 DM), ranging from eight to 26 years of age, were studied for cardiovascular autonomic function, and the relationship to age, duration...
Type 2 Diabetes Mellitus in Children
Jee Min Park, Eun Gyong Yoo, Duk Hee Kim
Clin Exp Pediatr. 2002;45(5):646-653.   Published online May 15, 2002
Purpose : The incidence of type 2 diabetes mellitus in children has been increasing worldwide recently, which is thought to be related to the increasing prevalence of obesity. We investigated to evaluate the incidence and the characteristics of type 2 diabetes mellitus in children and also analysed the relationship between intrauterine growth retardation and type 2 diabetes mellitus. Methods :...
Growth Hormone Receptor Mutation and Partial Growth Hormone Insensitivity in Children with Idiopathic Short Stature
So Chung Chung, Ran Namgung, Duk Hee Kim
Clin Exp Pediatr. 2001;44(8):922-935.   Published online August 15, 2001
Purpose : Children with idiopathic short stature(ISS) are classified on the basis of exclusion criteria. Short stature with normal or increased circulating growth hormone(GH) and low IGF-I levels indicates that partial growth hormone insensitivity(GHI) may play a role in ISS. The present study was performed to investigate whether partial GHI is observed in children with idiopathic short stature and whether...
The Usefulness of Fluorescence in Situ Hybridization(FISH) in the Diagnosis of Prader-Willi Syndrome
Young Ho Yang, Duk Hee Kim, So Chung Chung, Yong Seok Sohn, Mee Sun Kim
Clin Exp Pediatr. 2000;43(3):360-364.   Published online March 15, 2000
Purpose : To detect microdeletion of 15q11-13 region, high resolution cytogenetic analysis or FISH with probe at Prader-Willi syndrome region can be used. We tried to evaluate whether FISH with SNRPN is a more effective method than G-banding microscope in the diagnosis of Prader-Willi syndrome. Methods : Peripheral blood sampling was done on five patients who we suspected of Prader-Willi syndrome...
Changes in Fat Tissue and Growth Hormone Receptor mRNA after Growth Hormone Therapy
Hye Jung Shin, Duk Hee Kim, So Chung Chung, Kyungyoon Kam
Clin Exp Pediatr. 2000;43(2):247-252.   Published online February 15, 2000
Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We investigated the changes in fat tissue and GH receptor mRNA in adipose tissue...
Clinical Lecture
Therapeutic Effects of Growth Hormone Therapy in Short Children & Metabolic Disorders
Duk Hee Kim
Clin Exp Pediatr. 2000;43(2):165-171.   Published online February 15, 2000
Original Article
Growth Status and Levels of Growth Factors in Children with Insulin-dependent Diabetes Mellitus
So Chung Chung, Duk Hee Kim
Clin Exp Pediatr. 1998;41(8):1102-1110.   Published online August 15, 1998
Purpose : It is well known that the linear growth velocity in children with insulin-dependent diabetes mellitus(type 1 DM) is closely related to metabolic control and onset age of the disease. Many studies have demonstrated growth impairment in children with type 1 DM, regardless of the degree of metabolic control, whereas other studies have found no growth retardation. Therefore, we...
Case Report
Pseudohypoparathyroidism and Peudopseudohypoparathyroidism in a Family.
Young Cherl Lee, Duk Hee Kim, Chang Jun Coe
Clin Exp Pediatr. 1984;27(11):1128-1134.   Published online November 30, 1984
We are reporting the cases of 2 patients in a family, younger sister and elder brother, who exhibit skeletal and physiognomonic characteristic pictures of PHP and PPHP. In this report, we illustriated pertinent clinical and pathologic features of this diseases in children and revi- ewed the literature concerning this diseases.
Original Article
Allogenic bone marrow transplantation in rabbit.
Kir Young Kim, Duk Hee Kim, Young Mo Shon, Kwan Sub Chung, Hong Jin Kim, Duk Jin Yun
Clin Exp Pediatr. 1982;25(9):867-879.   Published online September 30, 1982
Allogenic bone marrow transplantation was done with Korean unspecified rabbits. Fresh bone marrow cell of different sex was infused to the recipient. The study group was divid- edfive groups according to immunosuppresive drugs. Each group was consited of 20 rebbits, was exposed to 1200 Rad. Group A, which were not have bone marrow transplantation, showed 100% mortality rate after 8 weeks. Group 8, which did not...
Case Report
Spondylometaphyseal Dyslpasia.
Kyo Sun Kim, Baik Keun Lim, Duk Hee Kim, Byung Ill Lee, Dae Young Han, Ki Keun Oh
Clin Exp Pediatr. 1980;23(9):748-752.   Published online September 15, 1980
There sibs with identical features of short-limbed dwarfism, a normal skull and face and normal intelligence are described. On the basis of the radiological and clinical characteristics, the condition must be included within the group of Spondylomephyseal dysplasia. In contract to the familial cases described up to now in which the mode of inheritance was autosomal dominant, the trait in...
A Case of Adrenocortical Insufficiency(hypoaldosteronism).
So Kyung Park, Seung Ju Lee, Keun Lee, Duk Hee Kim
Clin Exp Pediatr. 1980;23(9):741-747.   Published online September 15, 1980
A case of isolated hypoaldosteronism 5 month old male infant was presented. He was admitted to the pediatric ward with the chief complants of frequent vomiting, dehydration, lethargy and failure to thrive. The diagnosis was established by salt-losing manifestation, laboratory fiding and good response after salt-retaining steroid therapy. A brief review of related literatures were also presented.
A case of Scurvy.
Jun Hee Sul, Chul Lee, Duk Hee Kim, Pyung Kil Kim, Duk Jin Yun, Ki Keun Oh
Clin Exp Pediatr. 1980;23(9):730-736.   Published online September 15, 1980
Scurvy is a manifestation of deficiency of vitamin C, which was characterized by follicular hyperkeratosis, hemorrhagic manifestation, fatigue, muscular ache and pains, swollen jonts, swollen bleeding gums, and peripheral edema. Rescently we experienced a cases of scurvy in 13 month old boy who had been nourished by artificial feedings with ricegruel without additional vitamin C. Rentgenographic findings of bone revealed...
A Case of Achondroplasia.
Duk Hee Kim, Kwan Sub Chung, Baik Keun Lim, Duk Jin Yun
Clin Exp Pediatr. 1977;20(9):704-710.   Published online September 30, 1977
Achondroplasia is a rare disease and characterized by the combination of short extremities with an enlarged head and a trunk approximating normal size. We had experienced 4 cases of achondroplasia; they all showed stunted growth, short arms and legs, prominent forehead, flattening of the bridge of the nose and moderate degree of kyphcsis and one case was associated with hydrocephalus....
Original Article
Clinical observation of blood transfusion in infants and children
Jhong Young Jeon, Duk Hee Kim, Ki Young Lee, Duk Jin Yun
Clin Exp Pediatr. 1975;18(11):835-840.   Published online November 30, 1975
The transfusion of whole blood and its components had become part of the daily treatment of patients. The vast improvement of technics in blood collection and storage, combined with constantly increasing knowledge in the field of blood group immunology, has made it possible to operate blood transfusion service at a level of safety that may make the physician forget the...
Case Report
A Case of Total Anomalous Pulmonary Venous Return(A case report and review of literature)
Woo Gill Lee, Duk Hee Kim, Sun Hee Lee, Dong Shik Chin
Clin Exp Pediatr. 1973;16(2):151-155.   Published online February 28, 1973
We had a case of total anomalous pulmonary venous drainage, a 10 years old schoolboy who admitted to our Severance Hospital with chief problems of exertional dyspnea, palpitation, and known congenital heart disease since infancy. We confirmed this case as a total anomalous pulmonary venous connection to persistent left inno minate vein which drains into right atrium, atrial septal defect (secundum...
A Case of Infantile Cortical Hyperostosis
Sun Huh, Duk Hee Kim, Pyung Kil Kim, Kwan Ho Park, Yong Jae Lee
Clin Exp Pediatr. 1972;15(2):152-155.   Published online February 28, 1972
A case of infantile cortical hyperostosis is reported. The patient was 2 months old female who complained of mild fever and irritability, especially when changed her diaper. X-Ray showed marked periosteal elevation on the mandible, upper and lower extremities. Other laboratory tests were almost within normal limit. A brief review of literatures was made.