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Original Article
Neuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury
Mi Ju, Hyun Ju Lee, Sun Ju Lee, Eo Su Seo, Hye Jin Park, Kye Yang Lee, Gyeong Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Jong Won Lee, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2008;51(2):170-180.   Published online February 15, 2008
Purpose : Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain...
Cardioprotective Effects of Minocycline in Rat Myocardiac Cell Culture Induced by Hypoxia
Bum Seok Yang, Hye Jin Park, Hong Tae Kim, Jong Won Lee, Dong Suk Lee, Un Seok Nho, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2004;47(6):685-690.   Published online June 15, 2004
Purpose : Minocycline appears to reduce the mortality rate of patients with myocardial infarction. Therefore, the cardioprotective effects of minocycline through reduction of apoptosis were studied in a rat myocardiac cell culture induced by hypoxia. Methods : Cultured cells from the hearts of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% O2 and...
Neuroprotective Effects of Minocycline in Rat Brain Cortical Cell Culture Induced by Hypoxia
Kyung A Ha, Bum Seok Yang, Jin Kyung Kim, Hong Tae Kim, Sung Jin Ha, Jong Won Lee, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2003;46(11):1101-1106.   Published online November 15, 2003
Purpose : In vivo, minocycline appears to be neuroprotective. Thus, the neuroprotective effects of minocycline were studied in a rat brain cortical cell culture induced by hypoxia. Methods : Cultured cells from the brains of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% CO2 and hypoxia groups treated with 1% CO2. After several...
Hemorrhagic Shock and Encephalopathy Syndrome as a Cause of Sudden Death in Infants
Jong Won Lee, Chang Han Lee, Ki Sup Chung
Clin Exp Pediatr. 2000;43(6):814-819.   Published online June 15, 2000
Purpose : To evaluate the clinical characteristics, treatments and outcome of patients with hemorrhagic shock and encephalopathy(HSE) syndrome. Methods : We performed a clinical study on 14 patients who were diagnosed as hemorrhagic shock and having encephalopathy syndrome in the Department of Pediatrics, from 1984 to 1998. Age, sex, clinical symptoms and physical findings at admission, the most deranged laboratory findings,...
Case Report
A Case of 2q＋ Syndrome Identified by Fluorescent In Situ Hybridization
Hong Hee Lim, Soo Sung Park, Jong Won Lee, Eun Ryoung Kim, Mi Uk Jin, Nam Soo Park, IL Soo Kim
Clin Exp Pediatr. 1998;41(8):1144-1148.   Published online August 15, 1998
A Case of Pseudohypoaldosteronism
In Nam Kang, Jong Won Lee, Jin Guen Bang, Du Bong Lee
Clin Exp Pediatr. 1995;38(8):1160-1163.   Published online August 15, 1995
Psudohypoaldosteronism is a salt-wasting disease with unresponsiveness to mineralcorticoid and normal renal and adrenal function. Characteristic findings are severe hyponatremia, hyperkalemia and hyperaldosteronemia. We experienced a case of pseudohypoaldosteronism ina 1-day-old female who was presented with abdominal distension. Laboratory data showed hyponatrmia, hyperkalemia, elevation of plasma renin activity and aldosterone concentration and normal renal, adrenal function. We reported a case of...
A Case of Hereditary Anhidrotic Ectodermal Dysplasia
Jong Won Lee, Jin Kyung Jung, Jin Gun Bang, Jing Sam Rho, Jung Hee Park
Clin Exp Pediatr. 1994;37(10):1453-1456.   Published online October 15, 1994
Hereditary anhidrotic ectodermal dysplasia is a rare condition characterized by underdeveloped ectodermal structure including the skin, teeth or skin appendages. The patient has characteristic featureof anhidrosis, hypotrichosis and defective dentition. We experienced a case of hereditary anhidrotic ectodermal dysplasia in a 1-month-old male infant who had unexplained recurring fever, anhidrosis and characteristic facial feature, so we established the diagnosis with clinical...
Three Cases of Apert Syndrome (Acrocephalosyndactyly)
Young Sil Ahn, Jong Won Lee, Jin Keon Bang, Doo Bong Lee
Clin Exp Pediatr. 1994;37(8):1149-1155.   Published online August 15, 1994
Apert syndrome is an uncommon, congenital disorder characterised by malformation of the skull, most often acrocephaly or oxycephaly, in association with symmetrical syndactyly of both hands and feet. It is due to disturbance in the growth of bone and soft tissue affecting principally the head, the hands and the feet. The original description was presented by Troquart in 1886, and...
One Case of Aneurysm of Vein of Galen
Sun Young Lee, Jong Won Lee, Dong Joo Shin, Jin Keun Bang, Du Bong Lee, Kwang Woo Lee
Clin Exp Pediatr. 1994;37(7):1011-1015.   Published online July 15, 1994
Aneurysm of the vein of Galen is a rare midline arteriovenous malformation, usually presenting with cardiac failure in infancy or with hydrocephalus and raised intracranial pressure in older children. We experienced a case of the vein of Galen aneurysm diagnosed with computed tomographic (CT) features and magnetic resonance image(MRI), a new imaging modality. Our case was a 3 day-old male neonate...
Original Article
A Clinical Study of retinopathy of Prematurity
Jong Won Lee, Jin Kyung Jung, Ji Hae Kang, Ghee Young Jung, Moo Ung Kim
Clin Exp Pediatr. 1994;37(5):636-641.   Published online May 15, 1994
Among 666 premature infants or low birthweight infants who were admitted in NICU of st. Francisco General Hospital from January 1990 to Jun 1992, 96 infants were diagnosed as retinopathy of prematurity by indirect ophthalmoscope. The result were follows: 1) Among 666 patients, retinopathy of prematurity developed in 96 patients(14.1%) 2) The high incidence was observed in low birthweight and small gestational age. 3)...