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Case Report
Immunology
Concomitant use of corticosteroid and antimicrobials for liver abscesses in patients with chronic granulomatous disease
Kyung-Sue Shin, Mu Suk Lee
Clin Exp Pediatr. 2016;59(4):196-201.   Published online April 30, 2016

Chronic granulomatous disease (CGD) is a rare inherited disorder caused by defective nicotinamide adenine dinucleotide phosphate oxidase enzyme and characterized by recurrent bacterial and fungal infections. Although liver abscess is a common manifestation of CGD, its management in CGD patients is not well-defined. In addition, the generalized guidelines for treating liver abscesses do not necessarily apply to CGD patients. Corticosteroids...

Original Article
Long-term outcome of patients with p22phox-deficient chronic granulomatous disease on Jeju Island, Korea
Hyun Sik Kang, Geol Hwang, Kyung-Sue Shin
Clin Exp Pediatr. 2015;58(4):129-135.   Published online April 22, 2015
Purpose

This study investigated the long-term clinical outcomes of patients with p22phox-deficient chronic granulomatous disease (CGD) on Jeju Island and retrospectively evaluated the effects of interferon-gamma (IFN-γ) prophylaxis.

Methods

The medical records of 15 patients with CGD were retrospectively reviewed. The efficacy of IFN-γ prophylaxis was evaluated by comparing the frequency of severe infections before and after starting continuous prophylaxis with IFN-γ.

Results

At the...

Toll-like receptor 2 expression on monocytes from patients with BCG vaccine-associated suppurative lymphadenitis
Hyun Joo Oh, Kyung-Sue Shin
Clin Exp Pediatr. 2009;52(6):667-673.   Published online June 15, 2009
Purpose : Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections. The purpose of this study was to analyze TLR2 surface expressions and TLR2-mediated tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) production in patients with BCG vaccine-associated suppurative lymphadenitis. Methods : Peripheral monocytes were separated from 16 patients with BCG vaccine-associated suppurative lymphadenitis and 10 healthy...
Case Report
Familial systemic lupus erythematosus in two Korean male siblings
Hyun Sik Kang, Hyun Ju Oh, Young Ree Kim, Jae-Wang Kim, Kyung-Sue Shin
Clin Exp Pediatr. 2009;52(5):611-614.   Published online May 15, 2009
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been attributed to complex interactions between genetic and environmental factors, the influence of a genetic predisposition to SLE is supported by observations of familial aggregations. Family studies have found that siblings...
Original Article
TNF-α stimulated IL-8 and IL-10 expression in monocytes from patients with chronic granulomatous disease
Kyung-Sue Shin
Clin Exp Pediatr. 2008;51(10):1096-1101.   Published online October 15, 2008
Purpose : Patients with chronic granulomatous disease (CGD) have genetic mutations in a component of the NADPH oxidase enzyme that is necessary for the generation of the superoxide anion. The profound defect in innate immunity is reflected by the patients susceptibility to catalase-positive bacteria and fungi. In addition, CGD patients display signs of persistent inflammation, which is not associated only...
Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma
Kyung-Sue Shin, Youn Woo Kim
Clin Exp Pediatr. 2005;48(7):766-771.   Published online July 15, 2005
목 적 : 류코트리엔 수용체 길항제는 천식의 병리 반응에 관여하는 cysteiny leukotriene의 생성과 작용을 억제하여 급성기 천식 증상의 치료와 천식 증상의 조절 요법에 사용할 수 있다. 본 연구에서는 소아 천식환자에서 cysteinyl leukotriene 생성에 관여하는 LTC4S 유전자 다형태와 류코트리엔 수용체 길항제인 montelukast의 임상적 효과를 조사하여 약물유전학적 연관성 유무를 알고자 하였다. 방 법 : 환자군은 경증 지속성 천식과 중등증 지속성 천식환자 161명을 대상으로...
Association of Angiotensin-converting Enzyme Gene Polymorphism with the Disease Activity of Systemic Lupus Erythematosus in Korean Children
Kyung-Sue Shin
Clin Exp Pediatr. 2004;47(6):672-676.   Published online June 15, 2004
Purpose : Several recent studies have shown a significant association of angiotensin converting enzyme(ACE) gene polymorphism with systemic lupus erythematosus(SLE). The association has not been consistently confirmed; moreover, the association of ACE genotype with SLE in children has never been evaluated. The aim of this study is to evaluate the association of ACE gene polymorphism with SLE in Korean children. Methods...