Clinical and Experimental Pediatrics

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Original Article

The Effect of Postnatal Dexamethasone Treatment on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Chang Ro Park, Kyung Pil Park, Heng Mi Kim, Yoon Kyung Sohn

Clin Exp Pediatr. 2003;46(10):989-995. Published online October 15, 2003

Purpose : Dexamethasone is frequently administered to prevent or treat chronic lung disease in human neonates who are also prone to hypoxic-ischemic(HI) insults. Recently, meta-analysis of the follow-up studies reveals a significantly increased odd ratio for the occurrence of cerebral palsy or an abnormal neurologic outcome, and there is conflicting evidence regarding the impact of dexamethasone exposure on HI brain...

Effect of Resuscitation with High Concentration Oxygen on a Rat Model of Neonatal Hypoxic-Ischemic Brain Injury

Dong Seok Lee, Su-Hee Kwak, Heng-Mi Kim, Yoon Kyung Sohn

Clin Exp Pediatr. 2001;44(11):1278-1288. Published online November 15, 2001

Purpose : This study was undertaken to determine whether any features of apoptosis would occur in the established model of cerebral hypoxia-ischemia in neonatal rats. It was also undertaken to evaluate the effect of post-insult hyperoxia on hypoxic ischemic cerebral injury. Methods : Seven-day-old neonatal rats underwent unilateral carotid artery dissection followed by 2 hours of hypoxia. To this end...

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