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Case Report
Gastroenterology
Acute gastritis associated with Epstein-Barr virus infection in a child
Ji Mok Kim, Chun Woo Song, Kyu Sang Song, Jae Young Kim
Clin Exp Pediatr. 2016;59(Suppl 1):S68-S71.   Published online November 30, 2016

Infectious mononucleosis is Epstein-Barr virus (EBV) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. Gastrointestinal symptoms of EBV infection are nonspecific and occur rarely. EBV inducing acute gastrointestinal pathology is poorly recognized without suspicion. Careful consideration is needed to diagnose gastric involvement of EBV infection including gastric lymphoma, gastric cancer, and gastritis. A few...

Overlapping Guillain-Barré syndrome and Bickerstaff's brainstem encephalitis associated with Epstein Barr virus
Young Il Rho
Clin Exp Pediatr. 2014;57(10):457-460.   Published online October 31, 2014

A flaccid tetraparesis in Bickerstaff's brainstem encephalitis (BBE) is presumed to be a sign of overlapping Guillain-Barré syndrome (GBS). In addition, BBE and Fisher syndrome, which are clinically similar and are both associated with the presence of the immunoglobulin G anti-GQ1b antibody, represent a specific autoimmune disease with a wide spectrum of symptoms that include ophthalmoplegia and ataxia. A 2-year-old...

Original Article
Clinical features of Epstein-Barr virus-associated infectious mononucleosis in hospitalized Korean children
Keun Hyung Son, Mee Yong Shin
Clin Exp Pediatr. 2011;54(10):409-413.   Published online October 31, 2011
Purpose

Few studies have been conducted on the recent status of infectious mononucleosis (IM) in Korean children. The aim of this study was to evaluate the recent trend in the clinical manifestations of Epstein-Barr virus (EBV)-associated IM as well as the clinical differences according to age.

Methods

A retrospective study was performed on 81 children hospitalized with EBV-associated IM who fulfilled the serological...

Case Report
Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis
Yoon Young Jang, Kye Hyang Lee
Clin Exp Pediatr. 2011;54(9):389-393.   Published online September 30, 2011

We present the case of a patient with Epstein-Barr virus (EBV) encephalitis who developed abnormal white matter lesions during the chronic phases of the infection. A 2-year-old-boy was admitted for a 2 day history of decreased activity with ataxic gait. The results of the physical examination were unremarkable except for generalized lethargy and enlarged tonsils with exudates. Brain magnetic resonance...

A case of adolescent Kawasaki disease with Epstein-Barr virus-associated infectious mononucleosis complicated by splenic infarction
Byeong Sam Choi, Bo Sang Kwon, Gi Beom Kim, Yoon Kyung Jeon, Jung-Eun Cheon, Eun Jung Bae, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 2009;52(9):1029-1034.   Published online September 15, 2009
Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that affects children. There are few reports that describe the Epstein-Barr virus (EBV) as the possible infectious agent of KD. Here, we describe a case of KD in a 15- year-old boy complicated with giant coronary artery aneurysms, pericardial effusion, and splenic infarction. The clinical course of KD was...
Unrelated stem cell transplantation after reduced-intensity conditioning plus rituximab for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with CNS involvement
Hee Jo Baek, Hoon Kook, Dong Kyun Han, Min-Cheol Lee, Tae Woong Jeong, Tai Ju Hwang
Clin Exp Pediatr. 2009;52(6):725-729.   Published online June 15, 2009
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) with central nervous system (CNS) involvement is usually fatal unless stem cell transplant (SCT) is offered. However, SCT with conventional intensity conditioning is associated with high transplant-related mortality. We describe our experience with unrelated SCTs after reduced-intensity conditioning (RIC) for patients with EBV-HLH with progressive CNS disease. This approach was associated with minimal toxicities and...
Original Article
Clinical characteristics of Epstein-Barr virus infection detected by polymerase chain reaction in children less than 15 years old
Jong-In Na, Ok Lan Kim, Do-kyoung Seoung, Seong-Taek Yoo, Chang Woo Lee, Doo-Young Choi, Yeon-Kyun Oh, Ji-Hyun Cho, Jong-Duck Kim
Clin Exp Pediatr. 2008;51(11):1191-1197.   Published online November 15, 2008
Purpose : Previously, Epstein-Barr virus (EBV) infection was diagnosed by serological examination; currently, many EBV antigen detection methods have been developed and applied clinically for diagnosing EBV infection. To delineate the clinical characteristics of EBV infection, clinical and laboratory findings were evaluated for patients who tested positive in EBV polymerase chain reaction (PCR). Methods : EBV PCR was conducted in 352...
Detection of HHV6 and EBV in histiocytic necrotizing lymphadenitis
Kyung Hee Park, Sung Shik Park, Ji Yeon Kim, Su Eun Park
Clin Exp Pediatr. 2008;51(9):987-991.   Published online September 15, 2008
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis (HNL), is a self-limited disease characterized by cervical lymphadenopathy and fever. The etiology of KFD remains unknown; however, the self-limiting nature of HNL suggests the cause of this disease could be viral infection. For this reason, several viruses have been evaluated as possible etiologies of HNL, including Epstein-Barr virus (EBV), human...
Histiocytic necrotizing lymphadenitis in children : association of human herpes virus 8 and Epstein Barr virus
Hyun A Kim, Ju-Young Chung, Sang Woo Kim, Sung Jig Lim, Haeng Seop Shin
Clin Exp Pediatr. 2006;49(8):875-881.   Published online August 15, 2006
Purpose : The aims of this study were to analyze the clinical characteristics of children with Kikuchi's disease(KD) at a medical center and to investigate the etiologic role of human herpesvirus 8(HHV 8) or Epstein-Barr virus(EBV) in children with KD. Methods : Twenty six children who were diagnosed as KD between Jan. 1998 and Dec. 2005 were included....
A Study of Epstein-Barr Virus, and Human Leukocyte Antigen Typing in Children with Acute Infectious Mononucleosis
Seung-Hoon Hahn, Wan-Shik Shin, Hoon Han, Jin-Han Kang
Clin Exp Pediatr. 2003;46(5):467-473.   Published online May 15, 2003
Purpose : The Epstein-Barr virus(EBV), gamma herpesvirus, is an important pathogen that is widespread around the world. The EBV causes various diseases depending on the geographic location, and on the immunity or the premorbid condition of the person exposed to EBV. To evaluate EBV typing may be the most important step to figure out the pathogenesis of EBV associated diseases,...
Case Report
A Case of Chronic Active Epstein-Barr Virus Infection with Coronary Aneurysm
Hee Jeong, Bong Seong Kim, Ok Ja Choi, Han Wook Yoo, So Duk Lim, Soo-Jong Hong
Clin Exp Pediatr. 2001;44(6):687-693.   Published online June 15, 2001
Chronic active Epstein-Barr virus infection(CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for the Epstein-Barr virus(EBV). CAEBV is characterized by fever, lymphadenopathy, splenomegaly, hepatitis, interstitial pneumonitis, interstitial nephritis, and uveitis. Cardiovascular complications are rare in EBV infection. Patients with CAEBV show characteristically high titers of anti-viral capsid antigen(VCA) IgG antibody and anti-early antigen(EA) antibody, as well as relatively...
Original Article
Influence of Epstein-Barr Virus Infection on Outcome of Coronary Artery Lesions in Patients with Kawasaki Disease
Hye-Yung Ahn, Hyang-Sook Kim, Jo-Won Jung, Ki-Soo Pai
Clin Exp Pediatr. 2001;44(1):46-53.   Published online January 15, 2001
Purpose : Kawasaki disease(KD) may be linked to primary infection by certain common viruses. KD concurrent with Epstein-Barr virus(EBV) suggests the possibility of an etiologic agent related to the KD rather than to the EBV infection itself, but, the influence on coronary complication is unclear. To establish whether infection with EBV contributed to the outcome of coronary artery lesions in...
Detection of Herpes Viral DNA in Peripheral Blood of Kawasaki Disease Patient by Nested Polymerase Chain Reaction
Hae-Soon Kim
Clin Exp Pediatr. 2000;43(9):1180-1186.   Published online September 15, 2000
Purpose : Epidemiologic evidence suggests an infectious cause for Kawasaki disease(KD), but the etiology of KD remains unknown. The aim of this study was to determine whether viral infections are related in the pathogenesis of KD by detecting viral genomes using nested polymerase chain reaction. Methods : Peripheral blood was obtained from 18 acute KD patients before administration of intravenous gamma...
Typing of Epstein-Barr Virus in Healthy Korean Children and Adults
Jin Han Kang, Jae Kyun Hur, Joeng Hyun Kim, Ahn Hee Lee
Clin Exp Pediatr. 2000;43(5):644-649.   Published online May 15, 2000
Purpose : Recently, the list of Epsterin-Barr Virus(EBV)-associated diseases has been growing. It is now known that there are two types(type 1 & 2) of EBV, but it has yet to be fully investigated as to whether type B EBV differs in any way from type A virus in terms of geographical distribution or disease association. We performed this study...
Clinical Manifestations and Hematologic Complications of Epstein-Barr Virus Infection in Korean Children
Seong Hoi Jeon, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee, Young Chang Tocko
Clin Exp Pediatr. 1998;41(9):1216-1223.   Published online September 15, 1998
Purpose : Epstein-Barr virus(EBV) is associated with various diseases and complications caused by the host's immune reactions. This study focuses on various clinical findings and hematologic complications in childhood EBV infection. Methods : The study group was thirty-eight EBV infected children(Anti-EBV VCA IgM; positive) who were admitted to the Department of Pediatrics, Korea University from January 1996 to July 1997. Patients...
Epstein-Barr Viral Hepatitis in Childhood
Soo Kyung Lee, Ki Sup Chung
Clin Exp Pediatr. 1994;37(8):1124-1135.   Published online August 15, 1994
We analysed 58 patients who were admitted to the Department of Pediatrics, yonsei University College of Medicine due to infectious mononucleosis from January 1986 to August 1992. Of 58 patients who had responses to IgM to EBV viral capsid antigen and/or heterophil antibody, 35 patients had hapatitis. Of 35 hepatitis patients, group I consisted of 22 patients who had only...
Infectious Mononucleosis in Children
Woong Young Moon, Sei Ho Oh, Tae Sung Ko, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Dae Won Kim
Clin Exp Pediatr. 1994;37(6):822-831.   Published online June 15, 1994
We reviewed th eclinical findings of infectious mononucleosis and performed Epstein-Barr virus (EBV) serologic antibody tests in infectious mononuleosis and healthy group. One group was 18 cases of children, diagnosed as infectious mononucleosis who had been admitted to the department of Pediatrics. Asan Medical Center for two years and eight months. From November, 1989 to June, 1992. Another group was...
Prevalence of Epstein-Barr Virus (EBV) Antibody in Korean Children
Sei Ho Oh, Young Ah Lee, Woong Young Moon, Tae Sun Won, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Dae Won Kim
Clin Exp Pediatr. 1994;37(6):804-811.   Published online June 15, 1994
Recently, cases with typical clinical manifestations of infectious mononucleosis are increasing in Korea. So, to evaluate the recent epidemiology of EBV infection in Korea, we performed EBV serologic antibody tests for IgG antibody to EBV-viral capsid antigen (VCA) and antibody to EBV-associated nuclear antigen (EBNA) among the 108 healthy Korean infants and children whose ages were from newborn to 15...