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- Original Article
- Emergency Medicine
- Comparison of clinical features and laboratory findings of coronavirus disease 2019 and influenza A and B infections in children: a single-center study
- Meraj Siddiqui, Ayşe Gültekingil, Oğuz Bakırcı, Nihal Uslu, Esra Baskın
- Clin Exp Pediatr. 2021;64(7):364-369. Published online May 18, 2021
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Question: What are the differences between coronavirus disease 2019 (COVID-19) and influenza infections in children?
Finding: Pediatric COVID-19 patients predominantly exhibited respiratory and/or gastrointestinal symptoms, neurological manifestations, olfactory/gustatory dysfunction, elevated monocytes, mildly elevated C-reactive protein, and unilateral or diffuse abnormalities on chest x-ray. Patients with underlying medical conditions had higher intensive care unit admission rates and should be followed closely.
Meaning: The clinical presentations of pediatric COVID-19 patients varied from asymptomatic/mild to severe.
- Infection
- The impact of an educational intervention on parents' decisions to vaccinate their <60-month-old children against influenza
- Aery Choi, Dong Ho Kim, Yun Kyung Kim, Byung Wook Eun, Dae Sun Jo
- Clin Exp Pediatr. 2017;60(8):254-260. Published online August 14, 2017
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Purpose Seasonal influenza can be prevented by vaccination. Disease prevention in children aged <60 months is of particular importance because of the associated familial and societal burden. Considering that caretakers make the decision to vaccinate their children, the identification of drivers and barriers to vaccination is essential to increase influenza vaccination coverage.
Methods A total of 639 parents participated in the pre- and...
- Review Article
- Effectiveness and safety of seasonal influenza vaccination in children with underlying respiratory diseases and allergy
- Jin-Han Kang
- Clin Exp Pediatr. 2014;57(4):164-170. Published online April 30, 2014
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Influenza causes acute respiratory infections and various complications. Children in the high-risk group have higher complication and hospitalization rates than high-risk elderly individuals. Influenza prevention in children is important, as they can be a source infection spread in their communities. Influenza vaccination is strongly recommended for high-risk children with chronic underlying circulatory and respiratory disease, immature infants, and children receiving...
- Original Article
- Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons
- Seoung Geun Kim, Yoon Ha Hwang, Yung Hae Shin, Sung Won Kim, Woo Sik Jung, Sung Mi Kim, Jae Min Oh, Na Young Lee, Mun Ju Kim, Kyung Soon Cho, Yeon Gyeong Park, Sang Kee Min, Chang Kyu Lee, Jun Sub Kim, Chun Kang, Joo Yeon Lee, Man Kyu Huh, Chang Hoon Kim
- Clin Exp Pediatr. 2013;56(4):165-175. Published online April 22, 2013
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Purpose There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant influenza viruses during the 2007-2008 and 2008-2009 influenza seasons among patients who were treated with oseltamivir (group A) and those that did not receive oseltamivir (group B).
Methods A prospective study was conducted...
- Case Report
- Secondary paroxysmal dyskinesia associated with 2009 H1N1 infection
- Yun Jung Hur, Taegyu Hwang
- Clin Exp Pediatr. 2013;56(1):42-44. Published online January 29, 2013
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Neurological complications associated with 2009 H1N1 infection in children have been reported and recognized worldwide. The most commonly reported neurological complications are seizures and encephalopathy. Secondary movement disorders are also associated with the infection, but such cases are rarely reported. Here, we describe the case of a 14-year-old boy with paroxysmal kinesigenic dyskinesia secondary to 2009 H1N1 infection, who presented...
- Original Article
- Evaluation of immunogenicity of the 2008-2009 seasonal influenza vaccines by microneutralization test
- Seung Youn Kim, Yun Kyung Kim, Byung Wook Eun, Nam Hee Kim, Eun Kyeong Kang, Byong Sop Lee, Jung Sub Lim, Jun Ah Lee, Dong Ho Kim
- Clin Exp Pediatr. 2012;55(12):474-480. Published online December 20, 2012
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Purpose For evaluating the immunogenicity of an influenza vaccine, the microneutralization (MN) test has a higher sensitivity and specificity as compared to the hemagglutination inhibition (HI) test. However, the MN test is more time consuming and is difficult to standardize. We performed the MN test to determine its usefulness as an alternative or complementary test to the HI test for evaluating...
- Case Report
- A case of acute necrotizing encephalopathy associated with parainfluenza virus infection
- Yoo-Na Kim, Su Jeong You
- Clin Exp Pediatr. 2012;55(4):147-150. Published online April 30, 2012
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Acute necrotizing encephalopathy (ANE) may be suspected when a young child presents with abrupt onset of altered mental status, seizures, or both. Definitive clinical diagnosis is based on magnetic resonance imaging (MRI) results. ANE is associated with influenza virus infections. Preliminary data suggests that up to 25% of ANE patients die, and up to 25% of ANE survivors develop substantial...
- An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis
- Sang Teak Lee, Young June Choe, Won Jin Moon, Jin Woo Choi, Ran Lee
- Clin Exp Pediatr. 2011;54(10):422-424. Published online October 31, 2011
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Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically follows an infection or vaccination and has a favorable long-term prognosis. We describe the first reported case of ADEM after vaccination against novel influenza A (H1N1). A previously healthy 34-month-old boy who developed ADEM presented with a seizure and left-sided weakness 5 days after...
- Original Article
- Clinical characteristics of 2009 pandemic influenza A (H1N1) infection in children and the performance of rapid antigen test
- Yong-Jae Park, Jang-Yong Jin, Hyeon-Jong Yang, Woo-Ryung Lee, Dong-Hwan Lee, Bok-Yang Pyun, Eun-Sook Suh
- Clin Exp Pediatr. 2011;54(10):405-408. Published online October 31, 2011
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Purpose In autumn 2009, the swine-origin influenza A (H1N1) virus spread throughout South Korea. The aims of this study were to determine the clinical characteristics of children infected by the 2009 H1N1 influenza A virus, and to compare the rapid antigen and real-time polymerase chain reaction (PCR) tests.
Methods We conducted a retrospective review of patients ≥18 years of age who presented to...
- Case Report
- 2009 H1N1 influenza virus infection and necrotizing pneumonia treated with extracorporeal membrane oxygenation
- Suntae Ji, Ok Jeong Lee, Ji-Hyuk Yang, Kangmo Ahn, Joongbum Cho, Soo In Jeong, Woo-sik Han, Yae-Jean Kim
- Clin Exp Pediatr. 2011;54(8):345-349. Published online August 31, 2011
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A 3-year-old girl with acute respiratory distress syndrome due to a H1N1 2009 influenza virus infection was complicated by necrotizing pneumonia was successfully treated with extracorporeal membrane oxygenation (ECMO). This is the first reported case in which a pediatric patient was rescued with ECMO during the H1N1 influenza epidemic in Korea in 2009.
- Original Article
- Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region
- Seok Jeong Kang, Jae Min Lee, Jeong Ok Hah, Ye Jee Shim, Kun Soo Lee, Hyun Jung Shin, Heung Sik Kim, Eun Jin Choi, So Eun Jeon, Young Tak Lim, Ji Kyeong Park, Eun Sil Park
- Clin Exp Pediatr. 2011;54(3):117-122. Published online March 31, 2011
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Purpose Natural history and consequences of the novel 2009 influenza A H1N1 (2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological and oncological diseases.
Methods We retrospectively reviewed the medical records of 528 patients who had hematological and oncological diseases...
- Clinical characteristics of children with 2009 pandemic influenza A (H1N1) admitted in a single institution
- Sang In Park, Min Ji Kim, Ho Yeon Hwang, Chi Eun Oh, Jung Hyun Lee, Jae Sun Park
- Clin Exp Pediatr. 2010;53(10):886-891. Published online October 31, 2010
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Purpose This study aims to investigate the clinical characteristics of children diagnosed with the novel influenza A (H1N1) in the winter of 2009 at a single medical institution.
Methods Out of 545 confirmed cases of influenza A (H1N1) in children, using the real time RT-PCR method at Kosin University Gospel Hospital from September to December of 2009, 149 patients and their medical records...
- Oseltamivir efficacy, side effects, and safety in children with influenza
- Eun Sun Seo, Geun Hwa Park, Sung Won Kim, Sung Won Kim, Woo Sik Jung, Kyung Soon Cho, Yeon Gyeong Park, Chang Kyu Lee, Chun Kang, Joo Yeon Lee, Woo Young Choi
- Clin Exp Pediatr. 2010;53(1):56-66. Published online January 15, 2010
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Purpose : Although oseltamivir is widely used for treatment of influenza, few clinical studies of its efficacy and resistance have been performed in Korea. We evaluated the safety, side effects, and efficacy of oseltamivir treatment in Korean pediatric patients. Methods : We analyzed 321 children diagnosed with influenza at Busan St. Mary's Medical Center, Korea, between January 2008 and June... -
- Detection of nasopharyngeal carriages in children by multiplex reverse transcriptase-polymerase chain reaction
- Ji Hye Shin, Hye Young Han, Sun Young Kim
- Clin Exp Pediatr. 2009;52(12):1358-1363. Published online December 15, 2009
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Purpose : The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in children using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. Methods : We obtained nasopharyngeal swabs from 33 children without any underlying disease from July 25 to July 28, 2008. The children were free from the signs of respiratory tract infections at the... -
- Review Article
- Novel swine-origin H1N1 influenza
- Jina Lee, Hoan Jong Lee
- Clin Exp Pediatr. 2009;52(8):862-868. Published online August 15, 2009
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Since its identification in April 2009, a swine-origin H1N1 influenza A virus (S-OIV) which is a reassortment of gene segments from both North American triple-reassortant and Eurasian swine influenza has been widely spread among humans in unexpected rapidity. To date, each gene segment of the 2009 influenza A (H1N1) outbreak viruses have shown high (99.9%) neucleotide sequence identity. As of July 6, 94,512... -
- Original Article
- Risk factor of influenza virus infection to febrile convulsions and recurrent febrile convulsions in children
- Jae Won Moon, Jang Hee Kang, Hyun Ji Kim, Soon Ok Byun
- Clin Exp Pediatr. 2009;52(7):785-790. Published online July 15, 2009
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Purpose : Febrile convulsions are a common pediatric neurological disease, and it is important to prevent such a disease by controlling the risk factors that may recur. A recent report states that influenza virus infections have a high probability of a relationship with febrile convulsions; therefore, it is necessary to identify the clinical properties of febrile convulsions in relation to... -
- Bacterial meningitis in children experienced at a university hospital, 1993-2006
- Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
- Clin Exp Pediatr. 2008;51(10):1077-1084. Published online October 15, 2008
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Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients... -
- Antibody prsistence after Haemophilus influenzae type b (Hib) primary vaccination and response to boosters in Korean children
- Hyunju Lee, So Eun Park, Soo Young Lim, Kyong Min Choi, Hoan Jong Lee, Kyung Hyo Kim
- Clin Exp Pediatr. 2007;50(5):449-456. Published online May 15, 2007
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Purpose : Antibody persistence after primary series of Haemophilus influenzae type b (Hib) vaccine and responses to boosters are seldom studied in Korean children. We performed this study to evaluate the antibody titer in relation to booster immunization of Hib vaccine in Korean children. Method : One hundred forty four children aged 12-23 months were enrolled in three university hospitals. The... -
- A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005
- Yong Joo Lee, Soo Jin Lee, Ho Jin Park, Young Hyuk Lee, So Young Kang, Young Chang Kim, In Kyu Lee, Kyung Yeon Lee, Keon Su Lee, Won Seop Kim
- Clin Exp Pediatr. 2007;50(2):157-162. Published online February 15, 2007
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Purpose : The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area. Methods : We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals... -
- Validation of enzyme immunoassay for the quantitative measurement of human IgG antibodies specific for Haemophilus influenzae Type b capsular polysaccharide
- Kyung Hyo Kim, Soo Young Lim
- Clin Exp Pediatr. 2007;50(2):143-150. Published online February 15, 2007
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Purpose : This study was conducted to validate enzyme immunoassay (EIA) for the quantitative measurement of human IgG antibodies specific for Haemophilus influenzae type b (Hib) capsular polysaccharide. Method : We evaluated specificity, repeatability, intermediate precision, accuracy, lower limit of quantification (LLOQ), and stability to validate standardized EIA for the quantitative measurement of human anti-polyribosylribitol phosphate (PRP) IgG antibodies. Results :... -
- Review Article
- Present status and prospects of Haemophilus influenzae type b(Hib) immunization
- Kyung Hyo Kim
- Clin Exp Pediatr. 2006;49(3):242-250. Published online March 15, 2006
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Haemophilus influenzae type b(Hib) conjugate vaccines prevent Hib disease in individuals and reduce the carriage and transmission of the organism in the community. The incidence of Hib disease has been decreased dramatically in a diverse range of countries through the use of a variety of conjugate vaccines and vaccine schedules. In some countries, the vaccine has caused a near-disappearance of... -
- Original Article
- Clinical Usefulness of Rapid Antigen Test on the Diagnosis of Influenza
- Jae Seon Kim, Hyon Joo Choi, Young Min Ahn, Young Ok Hwang
- Clin Exp Pediatr. 2005;48(12):1348-1353. Published online December 15, 2005
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Purpose : Influenza is a respiratory disease which prevails widely every year and shows high morbidity and mortality among not only chronic invalids and the old, but also among infants and young children. To prevent community-acquired influenza infection, to facilitate prompt antiviral therapy and to avoid unnecessary use of antibiotics, an easy, rapid diagnostic method for the influenza virus is... -
- Clinical Effects of Oseltamivir in Children with Influenza in Busan, in the First Half of 2004
- Soo Kyoung Park, So Young Choi, Sung Mi Kim, Gil Heun Kim, Jin Hwa Jung, Im Jung Choi, Kyung Soon Cho
- Clin Exp Pediatr. 2005;48(9):976-985. Published online September 15, 2005
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Purpose : Although influenza is one of the most important causes of acute respiratory tract infections in children, effective antiviral therapies are not common and there are only a few clinical studies on treatment of influenza in children. We evaluated the efficacy of oseltamivir in the treatment of naturally aquired influenza in children during the first half of 2004 in... -
- Etiology and Clinical Features of Viral Lower-respiratory Tract Infections in Children in Winter, 2003
- Byung Ho Yun, Hee Chul Lee, Jung Mi Chun, So Young Yoon, Woo Gill Lee, Son Moon Shin
- Clin Exp Pediatr. 2005;48(7):723-730. Published online July 15, 2005
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Purpose : This study was performed to characterize the etiology and clinical features of acute viral lower-respiratory tract infections(LRI). Methods : Etiologic agents and clinical features of acute viral LRI were studied from October. 2003 through March. 2004 in hospitalized children with LRI(253 cases) at Samsung Cheil Hospital. The viruses were identified by indirect immunofluorescent method. Medical records of patients with... -
- Epidemiology and Clincal Analysis of Acute Viral Respiratory Tract Infections in Children(September, 1998-May, 2003)
- Su-Jin Lee, Eon-Woo Shin, Eun-Young Park, Phil-Soo Oh, Kwang-Nam Kim, Hae-Sun Yoon, Kyu-Man Lee
- Clin Exp Pediatr. 2005;48(3):266-275. Published online March 15, 2005
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Purpose : Acute respiratory tract infections are the most common illnesses in children. The great majority of these infections involving lower respiratory tracts infections(LRTIs) are caused by respiratory viruses such as respiratory syncytial virus(RSV), parainfluenza virus(PIV), influenza virus (Flu), and adenovirus(ADV), etc. Our purpose was to determine seasonal epidemiology and clinical characteristic features of each viral infection. Methods : Nasopharyngeal aspirate(NPA)s... -
- Retrospective Study for the Isolation of Influenza Virus and Prevalence Period in Busan from 2000 to 2002
- Chang Hwan Oh, Byeong Hee Son, Ki Dae Kim, Jung A Lee, Sung Won Kim, Kyung Soon Cho
- Clin Exp Pediatr. 2005;48(3):260-265. Published online March 15, 2005
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Purpose : During epidemics, influenza induces a high mortality and morbidity, and when influenza is prevalent, it is revealed by increased pneumonia, hospitalization due to influenza-like illness, and mortality in community. We aimed at the isolation of influenza virus and prevalence period in Busan from 2000 to 2002. Methods : For 3 years from 2000 to 2002, we analyzed the patterns... -
- Causative Organisms in Children with Bacterial Meningitis(1992-2002)
- Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
- Clin Exp Pediatr. 2003;46(11):1085-1088. Published online November 15, 2003
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Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles... -
- Case Report
- A Case of Influenza-associated Encephalopathy
- Yeoni Song, Chang Hwan Choi, Jong Woon Choi, Se Young Kim, Hyun Soo Kim, Yeol Kim, Dong Jin Im
- Clin Exp Pediatr. 2003;46(10):1024-1028. Published online October 15, 2003
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Influenza-associated encephalopathy is regarded as one of the major neurologic disease entities along with those of Reye syndrome, acute necrotizing encephalopathy, and myelitis which are known to be related to influenza virus, mostly type A. And it is being actively researched in Japan as it has caused a tremendous increase in the number of deaths from 1997 to 2002, but... -
- Original Article
- Clinical Analysis of Acute Respiratory Tract Infections by Influenza Virus in Children
- Min Kyoung Kwon, Mi Ran Kim, Eun Young Park, Kon Hee Lee, Hae Sun Yoon, Kwang Nam Kim, Kyu Man Lee
- Clin Exp Pediatr. 2002;45(12):1519-1527. Published online December 15, 2002
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Purpose : Although influenza virus is one of the most important causes of acute respiratory tract infections(ARTIs) in children, virus isolation is not popular and there are only a few clinical studies on influenza in Korea. We evaluated the epidemiologic and clinical features of ARTIs by influenza virus in children. Methods : From February 1995 to August 2001, nasopharyngeal aspirations were... -
- Carriage and Antimicrobial Susceptibility of Haemophilus influenzae Isolated from Oropharynges of Children
- Kyung Hyo Kim, Kyoung Ah Lim, Il Tae Whang, Young Mi Hong, Eun Sook Kang, Ki Sook Hong
- Clin Exp Pediatr. 2001;44(5):509-516. Published online May 15, 2001
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Purpose : Haemophilus influenzae, one of the normal flora of the upper respiratory tract, can cause such infections as otitis, sinusitis, pneumonia, and meningitis in children. The oropharyngeal flora has therefore mainly been analyzed as a reservoir for pathogens. This study was performed to reveal the colonization rate of H. influenzae in the upper respiratory tract, their biotypes, their antimicrobial... -
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Impact Factor3.2
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8.02023CiteScore94th percentilePowered by
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