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Case Report
A Case of Diffuse Panbronchiolitis Developing in Childhood
Jung Hoon You, Hyung Shin Lee, Kyung Yil Lee, Ja Hyun Hong, Mi Hee Lee, Byung Cheol Lee
Clin Exp Pediatr. 2005;48(1):97-100.   Published online January 15, 2005
Diffuse panbronchiolitis(DPB) is a chronic inflammatory airway disease predominantly affecting respiratory bronchioles, with distinct clinicopathological profiles. It was first described in 1966 by Yamanaka et al. The etiology of DPB is not yet clear, and the natural history of the disease is respiratory failure leading to cor pulmonale and ultimately death. But the long-term use of low-dose macrolide has proven...
Original Article
Outcome of Continuous Renal Replacement Therapy in Children
Yeon Jung Lim, Hyun-seung Jin, Hyewon Hahn, Sei Ho Oh, Seong Jong Park, Young Seo Park
Clin Exp Pediatr. 2005;48(1):68-74.   Published online January 15, 2005
Purpose : There is growing use of continuous renal replacement therapy(CRRT) for pediatric patients, but reports about the use and outcome of CRRT in children is rare in Korea. We report our experiences of CRRT in critically ill pediatric patients. Methods : We reviewed the medical records of 23 pediatric patients who underwent CRRT at Asan Medical Center between May 2001...
Comparison of Therapeutic Efficacy between Lamivudine and Alpha-Interferon in Korean Children with Chronic Hepatitis B at Two Years after the Initiation of Treatment
Byung-Ho Choe, You Cheol Jang, Chang Hwan Jang, Ki Won Oh, Jun Hwa Lee, Cheol Woo Ko
Clin Exp Pediatr. 2005;48(1):55-62.   Published online January 15, 2005
Purpose : We compared the therapeutic efficacy of lamivudine and alpha-interferon in children with chronic hepatitis B two years after the initiation of treatment, so that we could verify the safety and long term efficacy of lamivudine in children. Methods : We prospectively studied 44 children(32 male and 12 female; age, 1-18 years, mean, 9 years) treated for chronic hepatitis B...
Clinical Lecture
Benign Arrhythmias in Infants and Children
Jae Kon Ko
Clin Exp Pediatr. 2005;48(1):1-5.   Published online January 15, 2005
Pediatricians often encounter some electrocardiographic abnormalities in infants and children. However, treatment or referral to pediatric cardiologist is not indicated for all arrhythmias. Many of them are benign in nature. Benign arrhythmias can be defined as the arrhythmias that no serious problem currently exists and no treatment is needed. The prognosis of benign arrhythmias is so good that the condition...
Original Article
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
Clin Exp Pediatr. 2004;47(12):1319-1324.   Published online December 15, 2004
Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel...
A Clinical Study on Benign Convulsions with Mild Gastroenteritis
Jung Il Cho, Dong Wook Kim, Hyun Oh Jang, Jin Soo Moon, Seung Yeon Nam, Chong Guk Lee
Clin Exp Pediatr. 2004;47(12):1306-1311.   Published online December 15, 2004
Purpose : 'Benign convulsions with mild gastroenteritis(BCwMG)' is afebrile seizures associated with gastroenteritis without dehydration or electrolyte imbalance in young children aged almost 6 months to 3 years. Because seizures can occur repeatedly, patients can be misdiagnosed with epilepsy. Therefore, understanding the characteristics of this disease is thought to be important. This study was carried out to investigate the clinical...
Case Report
A Case of Spinal Cord Injury without Radiographic Abnormality
Seoung Joon Kim, Dae Kyun Koh, Jin Hee Oh, Jong Hyun Kim, Jung Soo Jun
Clin Exp Pediatr. 2004;47(11):1228-1231.   Published online November 15, 2004
A spinal cord injury without radiographic abnormality(SCIWORA) was defined by Pang and Wilberger in 1982 as the "objective signs of myelopathy as a result of trauma" in which no evidence of fracture, subluxation, or instability on plain radiographs, or computed tomography is demonstrable. Inherent elasticity of the vertebral column in infants and young children, among other age-related anatomical peculiarities, render...
Original Article
Prevalence of Metabolic Syndrome in Obese Children
Jin Ha Chang, Duk Hee Kim, Ho-Seong Kim, In Kyoung Choi, My Young Cheong, Dong Kee Kim
Clin Exp Pediatr. 2004;47(11):1149-1156.   Published online November 15, 2004
Purpose : Obesity has been known to be a cause of insulin resistance and dyslipidemia, and along with coronary artery disease and diabetes, is associated with metabolic syndrome(MS). This study aimed to ascertain the cause and prevalence of MS in obese children and adolescents. Methods : Two hundred and seventy-seven school children, who showed more than a 95th percentile of body...
Causative Organisms of Urinary Tract Infection in Children, and their Antibiotic Susceptibility
Yoon Duk Kang, Nam Su Kim, Sung Hee Oh
Clin Exp Pediatr. 2004;47(10):1065-1071.   Published online October 15, 2004
Purpose : In caring patients with urinary tract infection(UTI), it is prominent to know causative agents and their antimicrobial susceptibilities, of which domestic data appear somewhat different from those reported in the literature. The study was done to learn the distribution of pathogens causing UTI and their antimicrobial susceptibilities in Korean children. Methods : One hundred forty two inpatients diagnosed...
Elevated Circulating ICAM-1 and Eosinophil Cationic Protein in Children with Chronic Urticaria
You Sun Choi, Su A Shin, Young Dai Kim, Jae Won Oh, Ha Baik Lee
Clin Exp Pediatr. 2004;47(9):986-991.   Published online September 15, 2004
Purpose : Chronic urticaria is characterized by recurrent, itchy, and evanescent wheals over a period of six weeks. The mechanisms of chronic urticaria in children have not been fully elucidated. However, urticaria lesions represent a dynamic inflammatory process involving a complex interplay of various inflammatory mediators, chemokines, adhesion molecules and cellular interaction. The aim of this investigation was to elucidate...
Association of Angiotensin-converting Enzyme Gene Polymorphism with the Disease Activity of Systemic Lupus Erythematosus in Korean Children
Kyung-Sue Shin
Clin Exp Pediatr. 2004;47(6):672-676.   Published online June 15, 2004
Purpose : Several recent studies have shown a significant association of angiotensin converting enzyme(ACE) gene polymorphism with systemic lupus erythematosus(SLE). The association has not been consistently confirmed; moreover, the association of ACE genotype with SLE in children has never been evaluated. The aim of this study is to evaluate the association of ACE gene polymorphism with SLE in Korean children. Methods...
The Prevalence of Maturity Onset Diabetes of the Young(MODY) 3 in Children with Type 2 Diabetes Mellitus
In Kyoung Choi, Duk Hee Kim, Ho-Seong Kim, Nam Huh, Sang Hyun Paek, Seoung Young Jung
Clin Exp Pediatr. 2004;47(6):641-646.   Published online June 15, 2004
Purpose : Maturity-onset diabetes of the young(MODY) is a subtype of type 2 diabetes defined by autosomal dominant mode of inheritance, onset of diabetes usually before the age of 25 yrs, and a primary defect in the function of the beta cells of the pancreas. MODY3 is known as the most common form and is caused by mutations in hepatocyte...
Clinical Studies of Sinus Headache in Children
Eun Ah Lee, Chang Woo Lee, Doo Young Choi
Clin Exp Pediatr. 2004;47(6):617-622.   Published online June 15, 2004
Purpose : Headache is a common reason for children to seek medical care. There are many causes of headaches in children, such as migraine and its variants, tension, intracranial masses, and sinusitis. A high frequency of diagnosis of sinus headache, which specialists consider to be relatively rare, raises the possibility that migraine and other headache types are sometimes mistaken for...
Correlation between Percentage of Body Fat by BIA and Other Obesity Indices
Su Jin Kim, Su Yung Kim
Clin Exp Pediatr. 2004;47(5):491-495.   Published online May 15, 2004
Purpose : Obesity is becoming a serious health problem in schoolage children and adolescents. There are several parameters to estimate obesity such as body mass index(BMI), skinfold thickness, obesity index and weight for height. Each parameter has some advantages and disadvantages. Bioelectrical impedance analysis(BIA) seems to be a simple, reproducible, objective and cost effective method for fat evaluation. But there...
Assessment of Bronchial Hyperresponsiveness Using Chest Auscultation and Oxygen Saturation Measurement in Pre-school Children with a History of Wheezing
Young Yoo, Jinho Yu, Hee Kang, Eun Kyeong Kang, Young Yull Koh
Clin Exp Pediatr. 2004;47(4):417-423.   Published online April 15, 2004
Purpose : This study aimed to determine the efficacy and usefulness of chest auscultation and oxygen saturation measurement in the assessment of bronchial hyperresponsiveness to inhaled methacholine in pre-school wheezing children. Methods : One hundred and four children with histories of wheezing underwent bronchial challenges with nebulized methacholine using chest auscultation and oxygen saturation measurement. The challenge was considered positive when...
Case Report
A Case of Dieulafoy's Lesion in Duodenal Bulb
Jung Woo Rhim, Young Seok Kim, Jae Ock Park
Clin Exp Pediatr. 2004;47(3):343-346.   Published online March 15, 2004
Dieulafoy's lesion is an uncommon cause of recurrent massive gastrointestinal bleeding resulting from an abnormally large submucosal artery that protrudes through a small mucosal defect. Incidence of Dieulafoy's lesion as a source of upper gastrointestinal bleeding ranges from 0.3 to 6.7% in adults. But recently, the incidence is on an increasing trend by advanced endoscopic diagnostic technique. Lesions may occur...
Two Pediatric Patients with Neutropenia and Thrombocytopenia Associated with Parvovirus B19 Infection
Dong Koo Kim, Young Dai Kim, Ho Jun Lim, Sung Hee Oh, Hahng Lee
Clin Exp Pediatr. 2004;47(3):338-342.   Published online March 15, 2004
Parvovirus B19, a member of the Erythrovirus genus, is the only member of the Parvoviridae family known to be pathogenic in humans. Haematological consequences of B19 infection arise due to a direct cytotoxic effect on erythroid progenitors in bone marrow, resulting in interruption of erythrocyte production. The physiology of host haematopoiesis and competence of the immune response each determines clinical...
Original Article
Natural History of Chronic Hepatitis B in Children
Yuria Kim, Seoung Yeon Baek, Ji Hyun Eom, Ki Sup Chung
Clin Exp Pediatr. 2004;47(3):282-289.   Published online March 15, 2004
Purpose : We investigated the spontaneous seroconversion rate of hepatitis B viral markers and predictive factors affecting seroconversion in children with chronic hepatitis B. Methods : The study population included 214 children diagnosed as chronic hepatitis B, with positive HBsAg, HBeAg and HBVDNA over six months, and all patients had a family history of chronic Hepatitis B. They were followed between...
Observation on Causes of Adoption and Social Background of Children in Adoption Institution(5th Report)
Hak Sung Kim, Soo Yeon Kim, Sun Hee Kong, Dong Woo Lee, Kyung Eun Kim, Hye Jung Shin, Jae Yoon Kim
Clin Exp Pediatr. 2004;47(3):264-268.   Published online March 15, 2004
Purpose : Through a review of data provided by an adoption institution, this study was designed to provide a clue to help to reduce the abandonment of children by comparing the conditions at birth, social background, reason for request for adoption, and the degree of dependence on foreign adoption compared with the previous four reports. Methods : A total of 445...
Trend of Obesity in School Age Children in Seoul Over the Past 23 Years
Young Shin Park, Dong Hwan Lee, Joong-Myung Choi, Yun Ju Kang, Chong Hee Kim
Clin Exp Pediatr. 2004;47(3):247-257.   Published online March 15, 2004
Purpose : The aim of this study was to evaluate the change in prevalence and the epidemiology of obesity in school age children of Seoul, Korea during the last 23 years with coherency and under the same standards. Methods : We used the new 1998 standard weight for height to calculate obesity on the personal data from five years and produced...
Clinical Lecture
Helicobacter pylori Infection in Children : Recommendations for Diagnosis and Treatment
Yon Ho Choe
Clin Exp Pediatr. 2004;47(3):235-239.   Published online March 15, 2004
Helicobacter pylori(H. pylori) infection is mainly acquired in childhood. The prevalence of infection is still highest in children in the developing world. There has been a need for clinical guidelines for H. pylori infection in children. Therefore, the North American Society for Pediatric Gastroenterology and Nutrition and the European Paediatric Task Force on H. pylori achieved consensus and developed clinical...
Original Article
The Prevalence of Transfusion-Transmitted Virus Infection in Children
Ju Young Chung, Tae Hee Han, Eung Su Hwang
Clin Exp Pediatr. 2004;47(2):183-186.   Published online February 15, 2004
Purpose : Transfusion-transmitted virus(TTV) is an newly described nonenveloped human virus, with a circular, negative stranded DNA genome. Although a high prevalence of TTV infection in the normal population has been demonstrated, there is a still possibility of association with hepatitis according to the genotype of TTV. The aim of this study is to investigate the prevalence of TTV infection...
A Clinical Study on Mental Retardation of Preschool Children Diagnosed in Pediatric Developmental Clinic
Young Yeui Kim, In Kyung Sung
Clin Exp Pediatr. 2004;47(2):157-163.   Published online February 15, 2004
Purpose : Mental retardation, which can be defined as subnormal cognitive ability with markedly decreased ability to adapt to one's environment, is a common developmental disorder. But the diagnosis of mental retardation in young children is frequently missed in pediatric clinics. The purpose of this study is to increase the rate of early diagnosis and intervention by providing clinical information...
Clinical Observation of Mesenteric Lymphadenitis in Children
Chul Han Park, Dong Hoon Lee, Hye Lim Kim, Ji Min Park, Jin Bok Hwang, Heung Sik Kim, Hee Jung Lee
Clin Exp Pediatr. 2004;47(1):31-35.   Published online January 15, 2004
Purpose : Mesenteric lymphadenitis is classified into acute and chronic, specific and nonspecific types according to clinical aspect and causative disease. We under took this study to find out clinical aspects, associated diseases and hospital course of mesenteric lymphadenitis in children. Methods : We examined 98 children aged from 18 months to 14 years who visited Dongsan Medical Center for abdominal...
Clinical Lecture
Continuous Renal Replacement Therapy in Pediatrics
Hyewon Hahn, Young Seo Park
Clin Exp Pediatr. 2004;47(1):1-5.   Published online January 15, 2004
Original Article
Clinical Evaluation and Diagnosis of Children with Chest Pain
Su A Shin, Yong Joo Kim, Jae Whan Lee, Nam Su Kim, Soo Ji Moon
Clin Exp Pediatr. 2003;46(12):1248-1252.   Published online December 15, 2003
Purpose : Chest pain in the pediatric population is not rare and mostly benign. Causes of chest pain are diverse, and differential diagnosis is not easy. Chest pain in children is less likely to be cardiac in origin. Furthermore, chest pain in the pediatric population is rarely associated with life-threatening disease. This study was designed to evaluate children with chest...
The Utilities of Lung Biopsy in Pediatric Lung Disease
Jae Hee Lee, So Yeon Lee, Ja Hyung Kim, Bong Sung Kim, Soo-Jong Hong
Clin Exp Pediatr. 2003;46(12):1230-1234.   Published online December 15, 2003
Purpose : The aim of this study is to evaluate the value of lung biopsies for the management of children with lung disease. Methods : We retrospectively reviewed 19 lung biopsies done at Asan Medical Center, Seoul between 1993 and 2001. Data gathered included demographic information, underlying conditions, diagnosis before biopsy, final diagnosis, change in therapy, morbidity and mortality. Results : Nineteen...
Efficacy and Safety of Polyethylene Glycol(PEG) with Electrolytes for Disimpaction in Children with Chronic Functional Constipation
Hong Seop So, Sun Hwan Bae, Hei Sun Yoon, in Soon Hwang
Clin Exp Pediatr. 2003;46(11):1089-1094.   Published online November 15, 2003
Purpose : Polyethylene glycol(PEG) with electrolytes has been used for intestinal clearance for colonoscopy and operations in children. But its efficacy and safety for disimpaction in children with chronic functional constipation has been studied little. Methods : This study enrolled 26 patients with chronic functional constipation(11 children had failed to disimpaction by conventional management at OPD) who were admitted to the...
Causative Organisms in Children with Bacterial Meningitis(1992-2002)
Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
Clin Exp Pediatr. 2003;46(11):1085-1088.   Published online November 15, 2003
Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles...
Predictors of Clinically Non Specific Bacterial Infection in Febrile Children Less than 3 Years of Age : WBC, ESR and CRP
Jeong A Nho, Young Il Rho, Eun Seuk Yang, Eun Young Kim, Yeong Bong Park, Kyung Rye Moon
Clin Exp Pediatr. 2003;46(8):758-762.   Published online August 15, 2003
Purpose : Our examination was designed to determine the diagnostic properties of the cutoff point for the prediction of bacteremia in febrile children less than 3 years of age. Cutoff point is the value that simultaneously maximizes both sensitivity and specificity. Methods : We conducted a retrospective study of febrile children, less than 3 years of age, who clinically have no...