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Clincal Observations on Human Rotavirus (HRV) Gastroenteritis

Journal of the Korean Pediatric Society 1992;35(2):226-233.
Published online February 15, 1992.
Clincal Observations on Human Rotavirus (HRV) Gastroenteritis
Seung Ryong Han, Seung Hyun Seo, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
Human Rotavirus 위장염의 임상적 고찰
한승률, 서승현, 민기식, 김종완, 김광남, 유기양
한림대학교 의과대학 소아과학교실
Abstract
Clinical observations were made on 787 patients who were admitted to pediatric department of Kangdong Sacred Heart hospital because of watery diarrhea and vomiting between Jan. 1987 and Dec, 1989. ELISA study was done to detect HRV antigen for all patients. The results were as follows : 1) HRV antigen was detected in 492 patients (62.5%) by ELISA among 787 patients with watery diarrhea and vomiting. 2) Out of 192 patients who had HRV antigen, 409 patients (83.1%) were between 6~24 months of age. Most of the patients were seen durng cold seasons in autumn (57.1%) and winter (26.6%). 3) The mean duration of hospitalization was 5.4¡¾1.8 days in HRV gastroenteritis and 5.5¡¾2.1 days in non-HRV gastroenteritis. 4) The frequency of diarrhea less than 6 times per day was 67.3%(331/492) in HRV gastroenteritis and 67.8% (200/295) in non-HRV gastroenteritis. There was no difference in frequency of diarrhea between two groups. 5) In addition to diarrhea, the major symptoms in order of frequency were vomiting(79.9%), fever (45.7%), and coughing(22.8%) in HRV gastroenteritis, and vomiting( 53.6%), fever (50.5%), and coughing (31.5%) in non-HRV gastroenteritis. The incidence of vomiting in HRV gastroenteritis was higher than in non-HRV gastroenteritis (p<0.05). 6) AST elevation above normal was significantly increased in HRV gastroenteritis than non-HRV gastroenteritis (p<0.05). but ALT elevation between two groups was not correlated statistically. 7) Mean concentration of AST was significantly increased in HRV gastroenteritis than non-HRV gastroenteritis (p<0.05). but mean concentration of ALT between two groups was not correlated statistically.
Key Words: Human Rotavirus, Gastroenteritis


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