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Acquired Persistent Cytomegalovirus Infection : An Association with Common Variable Immunodeficiency

Journal of the Korean Pediatric Society 1992;35(9):1272-1279.
Published online September 15, 1992.
Acquired Persistent Cytomegalovirus Infection : An Association with Common Variable Immunodeficiency
Min Hyea Kim1, Young Mi Hong1, Sung Joo Lee1, Je Geun Chi2, Dong Soo Kim3
1Department of Pediatrics, Ewha Woman`s University College of Medicine, Seoul, Korea
2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
3Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
후천성 지속성 거대 세포 바이러스 감염 환아에 병발된 변형 면역 부전 1례
김민혜1, 홍영미1, 이승주1, 지제근2, 김동수3
1이화여자대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학과교실
3연세대학교 의과대학 소아과학교실
Abstract
Acquired persistent cytomegalovirus infection was diagnosed by anti CMV antibody and lymph node biopsy and persisted in a 3-year-old boy with recurrent episode of high fever, lymphadenopathy hepatosplenomegaly and pneumonia. Initial immunologic abnormalities including low serum IgG, high IgM decreased T4 and T4/T8 ratio finally progressed to immunologic paralysis which was compatible to common variable immunodeficiency. This is the first case which showed an association of acquired persistent cytomegalovirus infection with coimmon variable immunodeficiency. A related literature was reviewd.
Key Words: Persistent CMV infection, Immune disorder, Commom variable immunodeficiency


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