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Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)

Journal of the Korean Pediatric Society 1992;35(11):1509-1513.
Published online November 15, 1992.
Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)
Hyun Ho Shin1, Jae Yoon Kim1, Chong Woo Bae1, Sung Ho Cho1, Byoung Soo Cho1, Chang Il Ahn1, Young Tae Ko2, Moon Ho Yang3
1Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
2Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea
3Department of Anatomical Pathology, College of Medicine, Kyung Hee University, Seoul, Korea
고칼슘뇨증과 동반된 신병증
신현호1, 김재윤1, 배종우1, 차성호1, 조병수1, 안창일1, 고영태2, 양문호3
1경희대학교 의과대학 소아과학교실
2경희대학교 의과대학 방사선과학교실
3경희대학교 의과대학 병리학교실
Abstract
Idiopathic hypercalciuria is defined as excessive urinary excretion of calcium in normocalcemia without any primary cause. We performed the sono-guided percutaneous renal biopsy for patients of recurrent hematuria, persistent microscopic hematuria, proteinuria and RBC cast to evaluate underlying nephropathy. We could obtained the following results 1) The age at the renal biopsy ranged from 3 years to 14 years. Sex ratio is 1.9:1 (M:F) 2) The treatments of hypercalciuria were hydrochlorothiazide in 13 cases, and supportive management in 7 cases. 3) The results of renal biopsy were IgA nephropathy in 7 cases (35%), mesangium proliferative GN in 6 cases (30%), H-S-P nephritis in 2 cases (10%) and minor glomerular lesion in 5 cases (25%). In conclusion, even thought patients with hematuria show hypercalciuria by Stapleton and Coe et al, renal biopsy is mandatory especially when hypercalciuria associated with persistent or recurrent gross hematuria, massive proteinuria and RBC cast.
Key Words: Idiopathic hypercalciuria, Renal biopsy, Nephropathy


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