| The Significance of Nucleated Red Blood Cell Counts in Various Conditions Associated with Acute or Chronic Perinatal Asphyxia |
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Suck Kyu Hur1, Moon Sang Park1, Mee Kyung Namgoong1, Hwang Min Kim1, Jae Seung Yang1, Baek Keun Lim1, Jong Soo Kim1, Myung Seo Kang2 |
1Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea, Department of Radiology
2Department of Clinical Pathology, Wonju College of Medicine, Yonsei University, Wonju, Korea, Department of Radiology |
| 정상만삭아, 부당경량아, 미숙아, 신생아가사 및 유리질막증 환아에서의 말초유핵적혈구수의 의의 |
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허석규1, 박문상1, 남궁미경1, 김황민1, 양재승1, 임백근1, 김종수1, 강명서2 |
1연세대학교 원주의과대학 소아과학교실
2연세대학교 원주의과대학 임상병리학교실 |
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| Abstract |
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This study was conducted to find out the significance of nucleated red blood cell (NRBC) in neonates, especially associated with acute or chronic perinatal asphyxia. So, we compared NRBC counts in various neonatal groups, such as normal newborn, small for gestational age (SGA), premature, acute perinatal asphyxia, & hyaline membrane disease (HMD). In the first day of life, we examined Wright stained peripheral blood smear with light microscope, and counted NRBC/100 WBCs. We also calculated absolute NRBC count.
The results were as follows;
1) The average NRBC counts of normal newborns, fullterm SGA and premature appropriate for gestational age (AGA) neonates were 1.16/100 WBCs, 1.26/100 WBCs, 5.15/100 WBCs respectively. Also the average absolute NRBC counts were 1.34X109/L, 2.49X109/L, 6.73X109/L respectively. This data suggested that the average NRBC count of premature AGA neonates was higher than that of normal newborns.
2) The average NRBC count of asphyxiated fullterm neonates was 3.76/109 WBCs and the average absolute NRBC count was 6.49X109/L. So, we could conclude that the average NRBC count of asphyxiated fullterm neonates was much higher than that of normal newborns.
3) The average NRBC count of neonates with HMD was 17.76/100 WBCs and the average absolute NRBC count was 32.65X109/L. So, we could conclude that the average NRBC count of neonates with HMD was remarkably higher than that of other groups.
4) There was no significant difference between the two methods (NRBCS/100 WBCs, Absolute NRBC count) that could express NRBC counts.
In conclusion, NRBC counts were increased in various conditions such as prematurity, acute perinatal hypoxia, and HMD. |
| Key Words:
Nucleated red blood cell, Newborn, Premature, Small for gestational age, Neonation asphyxia, Hyaline membrane disease |
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