| Clinical Observation of Neonatal Sepsis |
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Jin A Son, Soon Wha Kim, Don Hee Ahn, Keun Chan Sohn |
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Department of Pediatrics, National Medical Center, Seoul, Korea |
| 신생아 패혈증의 임상적 관찰 |
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손진아, 김순화, 안돈희, 손근찬 |
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국립의료원 소아과 |
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| Abstract |
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Ninety two cases of culture proved neonatal sepsis who had been admitted to pediatric department, National medical Center, during 7 years from Jan, 1984 to Dec, 1990 were reviewed clinically and the following results were obtained.
1) The frepuency of neonatal sepsis was 3.1% and male to female sex ratio was 1.9:1, Sepsis was more prevalent in prenature infants (9.9%) than in full term infans (1.9%).
2) The seasonal incidence was more prevalent in summer (32.6%).
3) The weight distribution showed 50 cases with the weight less than 2500 gram and 42 cases more than 2500 gram.
4) In 76 cases the onset was before 7 days old and in 16 cases were developed after 7 days old.
5) The major associated perinatal conditions in neonatal sepsis were institutional baby (23.9%), premature rupture of membranes (11.9%) and placenta previa (4.3%) in the order of frequency. The clinical manifestations on admission were jaundice (50.0%), poor activity (46.7%), respiratory difficulty (35.9%), poor feeding (22.8%), cyanosis (22.7%), gastrointestional symptoms (21.5%), fever (15.2%) and convulsion (13.0%) in the order of frequency.
6) The associated diseases were urinary trct infection (31.5%), hyaline membrane disease (19.6%), congenital disorder (18.5%), pneumonia (15.2%), anemia (13.0%), meningitis (9.8%), omphalitis (7.6%), DIC (6.5%), necrotizing enterocolitis (5.4%) and intracranial hemorrhage (5.4%) in the order of frequency.
7) Causative organisms were gram positive organisms in 27 cases (25.7%) and gram negative organisms in 79 cases (74.3%). The main organisms were Serratia marcescens (18.5%), Enterobacter spp (17.4%), Klebsiclla pneumoniae (12.0%), Staphylococcus aureus (10.9%), Acinetobactor clacoaceticus (8.7%), Coagulase (-) staphylococcus (8.7%), E, coli (8.7%), Enterococcus (6.5%), Group B β-hemolytic streptococcus (5.4%) and Pseudomonas (5.4%) in the order of frequency.
The sensitivity to antibiotics were.
Senatia marcescens; 70.6% sensitive to Amikacin
58.9% sensitive to Cefotaxime
Enterobacter spp : 87.5% sensitive to Amikacin
68.6% sensive to Cefotaxime
Klebsiella pneumoniae : 100% sensitive to Amikacin
91.0% sensitive to Cefotaxime
Staphylococcus aureus : 100% sensitive to Cefazolin
90.0% sensitive to Cefotaxime
Acinetobacter calcoaceticus : 88.9% sensitive to Amikacin
Coagulases (-) Staphylococcus : 100% sensitive to Amikacin
87.5% sensitive to Cefotaxime
E.coli : 100% sensitive to Amikacin, Cefotaxime
Enterococcus : 50% sensitive to Gentamicin, Ampicillin, Amikacin
Group Bβ- hemolytie Streptococcus : 100% sensitive to Ampicillin, Penicillin
Pseudomonas : 100% sensitive to Amikacin, Gentamicin, Tobarmycin
8) Mortality cases were 32 cases (34.8%). |
| Key Words:
Neonate, Sepsis |
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