| Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage |
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Choon Haeng Lee1, Sang Joo Han1, Hong Jin Lee1, Won Il Park1, Kyung Ja Lee1, Young Eui Park2, Min Chul Lee2, Tae Heon Yoon3 |
1Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
2Department of Pathology, College of Medicine, Hallym University, Seoul, Korea
3Korean Institute of Nutrition, Hallym University, Chuncheon, Korea |
| Adriamycin에 의하여 유발된 S-D rat의 신증후군에 있어서 단백질 섭취량의 변화에 따른 예후의 비교 |
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이춘행1, 한상주1, 이홍진1, 박원일1, 이경자1, 박영의2, 이민철2, 윤태헌3 |
1한림대학교 의과대학 소아과학교실
2한림대학교 의과대학 병리학교실
3한림대학교 한국 영양연구소 |
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| Abstract |
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We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks
1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight loss were more marked and 2 rats died due to severe ascites and pleural effusion in cachexic state
2) In rats fed with high protein diets(30%), general health condition and weight gain were relatively well preserved. But there were massive proteinuria, progressive increase in serum creatinine and progressive decrease in creatinine clearnce. Focal glomerular sclerosis and severe tublulointerstitial change on histologic examination were marked.
3) With intermediately low protein diet(10%), renal function and pasma protein levels were relatively well preserved compared with high protein diet group. But weight gain did not increase normally
4) We tentatively conclude that appropiately restricted dietary protein can prevent functional and histological renal damage. But too strict protien restriction aggravate nutitional state and general condition. |
| Key Words:
Adriamycin-nephropathy, Protein restriction, Renal failure |
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