| Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children |
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Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang |
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Department of Pediatrics, Catholic University Medical College, Seoul, Korea |
| 소아 재발성 중추신경계 백혈병에 대한 간헐적 중추신경계 방사선 조사 및 수막강내 화학요법 |
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방준호, 정낙균, 최우건, 김학기, 이경수, 양만규 |
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가톨릭대학교 의과대학 소아과학교실 |
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| Abstract |
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Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence of CNS leukemia. This experience suggests that IIIC may be an effective treatment for preventing the recurrence of CNS leukemia without any serious side effects. |
| Key Words:
Acute lymphocytic leukemia, CNS irradiation, Intrathecal chemotherapy |
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