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Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns

Journal of the Korean Pediatric Society 1993;36(9):1219-1226.
Published online September 15, 1993.
Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns
Ki Young Koo, Nam Geun Heo, Heng Mi Kim
Department of Pediatrics, College of Medicine, Kyung-Pook National University, Taegu, Korea
정상 신생아와 가사 신생아에 있어서의 Ceatine Kinase의 출생후 변화
구기영, 허남근, 김행미
경북대학교 의과대학 소아과학교실
Abstract
This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK)and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5% of total CK during study period. In asphyxiated newborns total CK, CK-MM and CK-MB reached maximal value at 12hr after birth whereas CK-BB decreased after birth. There were no significant differences between normal and asphyxiate newborns in total CK, CK-MM and CK-MB during study period (up to 24 hrs after birth). But CK-BB of asphyiated newborn was elevated significantly(p<0.05)within 6 hrs after birth compared to normal newborns. There were no significant differences of CK and its isoenzymes between patients evaluated by 5min Apgar scores(0~3, 4~6 and 7~10) or degree of HIE (HIE stage 0~Ⅰ, Ⅱand Ⅲ). According to these results, the serum CK-BB is elevated in asphyxiated newborns during 1st 6hrs after birth but has no predictive values of the extent of cerebral damage.
Key Words: Asphyxia, Creatine kinase


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