| Phenobarbital Dosage and Blood Level for Control of Neonatal Seizure |
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Hye Soon Kim1, Keun Lee1, Young Sook Ko2 |
1Department of Pediatrics, Ewha University, College of Medicine, Seoul, Korea
2Department of Pediatrics, Daerim St. Mary`s Hospital, Seoul, Korea |
| 신생아 경련시 Phenobarbital 부하량과 혈중농도에 관한 연구 |
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김혜순1, 이근1, 고영숙2 |
1이화대학교 의과대학 소아과학교실
2대림성모병원 소아과 |
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| Abstract |
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Twenty-five neonates was observe for the relationship between phenobrbital loading dose, plasma concentrations and control of seizures. Nineteen neonates (76%) had seizures controlled by phenobarbital alone, Effective plasma concentration were 10.0~31.3㎍/ml. Although 14 neonates had seizures controlled by phenobarbital concentration below 20㎍/ml, neonate required level above 30㎍/ml. We foound that continued benefit was obtained until phenobarbital plasma concentrations reached 40㎍/ml and there was no abverse effects on cardiorespiratory function. We recommend that plasma phenobarbital concentrations should equal or surpass 40㎍/ml before additional anticonvulsants are used for neonates with seizure. |
| Key Words:
Neonatal convulsion, Phenobarbital |
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