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Improvement of Thoracic Pressure-Volume, Complincace and Histological Characteristics in Premature Newborn Rabbit after Treatment of Bovine Purified Natural Surfactant-Phospholipid

Journal of the Korean Pediatric Society 1994;37(2):157-166.
Published online February 15, 1994.
Improvement of Thoracic Pressure-Volume, Complincace and Histological Characteristics in Premature Newborn Rabbit after Treatment of Bovine Purified Natural Surfactant-Phospholipid
Chong-Woo Bae1, Chang Il Ahn2, Haruo Maeta3, Tetsuro Fujiwara3
1Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Korea
3Department of Pediatrics, Iwate Medical University, Morioka, Japon
토끼 태아 RDS 모델에서 Bovine Purified Natural Surfactant 보충요법 후 폐기능 및 조직학적 개선에 관한 연구
배종우1, 안창일2, 前多治雄3, 藤原哲郞3
1경희대학교 의과대학 소아과학교실
2경희대학교 의과대학 소아과학교실
3日本岩手醫科大學 小兒科
Abstract
We had previously reported the purification of bovine lung natural surfactant-phospholoipd (PNS-L) and the assessment of it's surface physical properties in vitro. To observe the clinical effectiveness of PNS-L in vivo, the degree of improvement of thoracic pressure-volume, compliance and histological changes following PNS-L instillation in premature rabbits with respiratory distress syndrome (RDS) were investigated. Rabbits, delivered prematurely by cesarean section at 27days, treated with PNS-L via tracheostomy, were enrolled the study group. Two control groups were premature RDS rabbits (no treatment with PNS-L) and mature rabbits. We compared the results of thoracic pressure-volume changes during deflation phase and lung compliance changes among PNS-L treated study group and two control groups, and compared the results of aerated lung area ratio (%) on histologic samples among PNS-L treated study group and two control groups by the methods of IBSA-2000. There were significant improvements of thoracic pressure-volume during deflation phase (p<0.001), lung compliance (p<0.01, p<0.005, p<0.001) and increased aerated area histologically (p<0.005) in PNS-L treated study group compared with premature control group. It was suspected that PNS-L had contained the effective surface physical properties as a function of pulmonary surfactant. And improvement of pulmonary ventilatory functions and histological characteristics, were observed in PNS-L treated RDS model in vivo study.
Key Words: Pulmonary surfactant, Neonatal respiratory distress (RDS), Animal model of RDS, Replacement of surfactant


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