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Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique

Journal of the Korean Pediatric Society 1994;37(2):231-239.
Published online February 15, 1994.
Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique
Jin Sook Kim1, Young Ran Yoon1, Mi Kyung Kim1, Hye Kyung Han1, Mi Ryung Um1, Kyung Hoon Choi1, Mi Na Lee1, In Keol Moon2, In Kweon Han3
1Department of Pediatrics , Cheil General Hospital, Seoul, Korea
2Laboratory of Endocrinology, Cheil General Hospital, Seoul, Korea
3Department of Internal Medicine, Cheil General Hospital, Seoul, Korea
중합효소 연쇄반응(Polymerase Chain Reaction, PCR)을 이용한 보균산모와 신생아에서 B형 간염 Virus의 수직 감염에 관한 연구
김진숙1, 윤영란1, 김미경1, 한혜경1, 엄미령1, 최경훈1, 이미나1, 문인걸2, 한인권3
1제일병원 소아과
2제일병원 내분비연구실
3제일병원 내과
Abstract
Total 8,341 pregnant women who visited Obstetric clinic Cheil General Hospital from January 1991 to July 1992 were screened for HBsAg. Sixty five women with positive HbsAg who delivered healthy babies during that period and their infants are included in the study. HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were tested by radioimmunoassay and hepatitis B virus DNA were studied by polymerase chain reaction technique in both mother's and babies serum. The results were as follow: 1) among 8,341 pregnant women who were screened for HBsAg 374 were asymptomatic carriers(4.5%). 2) The newborn babies born to 65 mothers who were positive HBsAg showed HBsAg in 4.6%, HBeAg 75.0%, anti-HBc 98.4% and hepatitis B virus DNA in 26.2%. 3) It showed discordance of HBeAg/anti-HBe, with hepatitis B virus DNA in newborn infants. 4) Follow up study at 8~20 months showed HBeAg and hepatitis B virus DNA in 2 infants out of 20.
Key Words: Hepatitis B virus, Polymerase chain reaction, Carrier


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