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The Metabolic Acidosis and Clinical Outcome in Acute Infantile Diarrhea

Journal of the Korean Pediatric Society 1994;37(3):332-338.
Published online March 15, 1994.
The Metabolic Acidosis and Clinical Outcome in Acute Infantile Diarrhea
Ae Yeon Lim, Yo Ahn Rho, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Department of Pediatrics, Korea University, College of Medicine, Seoul, Korea
영아기 급성 설사에 있어서 대사성 산혈증과 임상경과에 관한 연구
임애연, 노요안, 유기환, 이주원, 김순겸
고려대학교 의과대학 소아과학교실
Abstract
To determine the types of metabolic acidosis using anion gap in acute infantile diarrhea and to correlate it with clinical outcome, we examined 103 infants admitted with acute diarrhea. The serum electrolytes (sodium, potassium, chloride, phosphorus), creatinine, CO2 content and anion gap were measured on first admission day. They were classified group A with normal anion gap (8~16 mEq/L) and group B with increased anion gap (>16 mEq/L). The results were as follows. 1) The number of group A with normal anion gap (11.6¡¾3.3mEq/L) was 62 and the number of group B with incresed anion gap (21.1¡¾5.5mEq/L) was 38. 2) The duration of diarrhea was significantly prolonged in group B (9.0¡¾2.5days), compared with group A (5.9¡¾1.1days) (p<0.001). 3) The duration of admission was significantly prolonged in group B (5.6¡¾2.2days), compared with group A (4.0¡¾1.4days) (p<0.001]. 4) Infants in group B, compared with group A, were significantly more severe dehydrated (p<0.001). 5) Infants in group B demonstrated significant elevations of total protein, creantinine, phosporus, compared with group A (p<0.001). 6) Growth parameters such as weight, head circumference and chest circumference were significantly lower in group B than group A, but there was no significant difference between two groups in height (p<0.05). In conclusion, infants with increased anion gap in acute diarrhea associated with severe dehydration, prolonged diarrhea and prolonged duration of admission. Therefore, we suggest that in acute infantile diarrhea, the anion gap can be used in clinical treatment and determination of prognosis.
Key Words: Anion gap, Infantile diarrhea


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