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Clinical Observation of Neonatal Group B β-Hemolytic Streptococcal Meningiti

Journal of the Korean Pediatric Society 1994;37(3):347-355.
Published online March 15, 1994.
Clinical Observation of Neonatal Group B β-Hemolytic Streptococcal Meningiti
Yeon Chung Chung, Mi Won Kim, Yong Kyu Lee, Yun Jong Kang, Jung Wan Seo, Jin Keun Chang
Department of Pediatrics, Hanil Hospital, Seoul, Korea
Group B β-hemolytic Streptococcus에 의한 신생아 뇌막염의 임상적 고찰
정연정, 김미원, 이용규, 강윤종, 서정완, 장진근
Neonatal meningitis caused by the Group Bβ-hemolytic streptococcus was first reported in 1958. In recent years this organism has assumed major importance in the etiology of neonatal infection. In Korea, this organism is likely to play an increasing role in neonatal infection. So this investigation was designed to report the 9 cases of Group B β-hemolytic streptococcus infected neonates admitted to the NICU, department of Pediatrics, Hanil Hospital from January 1990 to June 1993. The results were as followings. 1) Onset of disease was between 12days and 32days of age and male to female ratio is 1:2. 2) Two cases were delivered by c-section, seven cases were by NFSD and all of the infants had normal birth weight with full term at delivery. Maternal obstetric and neonatal complications were not detected in all cases. 3) The common presenting symptoms were fever in all cases, seizure in 6 cases, feeding difficulty, lethargy, vomiting, etc. 4) Group B β-hemolytic streptococcus was isolated in CSF of all cases and in blood of 6 cases. 5) There were abnormal brain CT findings in 4 cases of group B β-hemolytic streptococcal meningitis. 6) The sensitive antibiotics were Cefotaxime, Cefazoline, Erythromycin, Ampicillin, chloramphenicol, Clindamycin and Penicillin. 7) All cases were recovered except one case that expired on the 1st day of admission and 6 cases were followed up for the period of 2months to 33months without neurologic sequelae, of which 1 case revealed decreased wave on Lt. hemisphere in ABR.
Key Words: Group B streptococcal meningitis, Newborn

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