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A Clinical Study on Childhood Leukemia

Journal of the Korean Pediatric Society 1994;37(5):655-665.
Published online May 15, 1994.
A Clinical Study on Childhood Leukemia
Joo Huh, Jong Bum Shin, Soon Yong Lee
Department of Pediatrics, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
소아 백혈병에 대한 임상적 고찰
허주, 신종범, 이순용
인제대학교 의과대학부속 부산백병원 소아과학교실
Clinical analysis of 170 patients with childhood leukemia was made, who were admitted to the department o Pediatrics, Pusan Paik Hospital, Inje University, College of Medicine during 10 years from 1981 to 1990. The results were as follows: 1) The annual number of the patients with childhood leukemia was in the range of 6~25 cases. And the annual rate of the number of childhood leukemia inpatients to the patients in the department of the Pediatrics was 0.37~1.60% with the average of 1.06%. 2) Of the 170 Patients, 72 cases(42.3%) were in the range of 0~5 years of age, which was the largest age group. In male, of the 97 patients, the largest age group was the age group of 0~5 years, which included 45 cases(46.4%), while in female, the largest was that of 6~10 years, which included 29 cases of 73 patients(39.8%). 3) Of the 170 patients, sex ratio was 1.33:1 with male dominance in all age groups except 1:1.6 with female dominance in the age group of 6`10 years. 4) Of the 170 patients, 113 cases were ALL(66.5%), 50 cases AML(29.4%), and 7 cases CML (4.1%). 5) In ALL, 51 cases of the 113 patients(45.1%), were in the age group of 0~5 years, 35 cases(31%) in the age group of 6~10 years, and 27 cases(23.9%) in the age group of 11~15 years. In AML, 19 cases of the 50 patients(38.0%) were in the age group of 0~5 years, 17 cases(34%) in the age group of 6~10 years, and 14 cases(28%) in the age group of 11~15 years. 6) In ALL, the sex ratio of male:female was 1.21:1, 1.50:1 in AML, and 2.5:1 in CML. 7) According to the FAB classification in ALL, of the 113 patients, 72 cases(63.7%) were in L1 type, 34 cases(30.0%) in L2 type, and only 3 cases in L3 type. In AML, of the 50 patients, 19 cases (38%) were in M2 type, 16 cases(32%) in M1 type, and 6 cases(12%) in M4 type, in order. 8) In CML, of the 7 patients, 4 cases were juvenile type, who were all under 10 years old, while 3 cases were adult type, who were all male above 11 years old. 9) Of the 170 patients, clinical symptoms on admission were pallor in 112 cases(65.9%), fever in 84 cases(49.4%), hemorrhage in 78 cases (45.9%), weakness in 40 cases(25.3%), bone pain in 32 cases(18.8%) in order. 10) Of the 170 patients, physical findings on admission were hepatomegaly in 113 cases(66.5%), lymphnode swelling in 84 cases(49.4%), splenomegaly in 78 cases(45.9%) in order. 11) Of the 170 patients, the hemoglobin level on admission were 4~7gm/dl in 95 cases(55.9%), 8~10gm/dl in 42 cases(24.7%), and 0~3gm/dl in 22 cases(12.9%) in order. 12) Of the 170 patients, the WBC count on admission were 10,000~50,000/mm3 in 58 cases(34.1%), below 5,000/mm3 in 49 cases(28.8%), and 5,000~100,000/mm3 in 24 cases (14.1%) in order. 13) Of the 170 patients, the platelet count on admission were below 50,000/mm3 in 93 cases(54.7%), above 100,000/mm3 in 48 cases(28.2%), 20,000~50,000/mm3 in 43 cases(25.3%), and 50,000~100,000/mm3 in 29 cases(17.1%) in order.
Key Words: Childhood leukemia, ALL, AML, CML

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