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Infectious Mononucleosis in Children

Journal of the Korean Pediatric Society 1994;37(6):822-831.
Published online June 15, 1994.
Infectious Mononucleosis in Children
Woong Young Moon1, Sei Ho Oh1, Tae Sung Ko1, Young Seo Park1, Hyung Nam Moon1, Chang Yee Hong1, Dae Won Kim2
1Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea
2Department of Clinical Pathology, College of Medicine, University of Ulsan, Seoul, Korea
소아의 전염성 단핵구증
문웅영1, 오세호1, 고태성1, 박영서1, 문형남1, 홍창의1, 김대원2
1울산의대 소아과
2울산의대 임상병리과
We reviewed th eclinical findings of infectious mononucleosis and performed Epstein-Barr virus (EBV) serologic antibody tests in infectious mononuleosis and healthy group. One group was 18 cases of children, diagnosed as infectious mononucleosis who had been admitted to the department of Pediatrics. Asan Medical Center for two years and eight months. From November, 1989 to June, 1992. Another group was 20 cases of healthy 5-year old children. The results were as follows: 1) The age distributions of 18 patients with infectious mononucleosis were as follows: nine patients were less than 5 year old and nine patients (50%) were older than 5 year old. 2) The hematologic findings revealed increased atypical lymphocytes in sixteen patients(88%), leukopenia in one patient(6%), thrombocytopenia in one patient (6%), In addition, we observed transient hepatitis in eight patients (44%) and jaundice in one patient (6%). 3) Hemophagocytic sydrome was developed in one patient who expired due to meningitis. 4) The heterophil antibody tests were positive in two cases (11%) out of eihteen infectious mononucleosis patients. 5) EBV serologic antibody tests for IgM antibody to EBV-viral capsid antigen (VCA) in 18 patients were all positive, which implies primary infection. 6) EBV serologic antibody tests for IgG antibody to EBV-VCA and antibody to Epstein-Barr nuclear antigen (EBNA) in helathy 5-year old children were negative in 3 cass (15%) out of 20 cases each other, which suggests primary infection might occur afer five years of age. 7) Recently, more cases of clinically typical infectious mononucleosis are detected and the onset of EBV primary infection is becoming late in Korea, which is thought to be due to economic developments and improvements of environmental hygine. And we recommend EBV serologic antibody test for the confirmative diagnostic test of infectious mononucleosis.
Key Words: Epstein-Barr virus, Infectious Mononucleosis, EBV serologic antibody test

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