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Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System

Journal of the Korean Pediatric Society 1994;37(10):1386-1396.
Published online October 15, 1994.
Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System
Kwang-Ju Lee, Young-Hun Chung, Jae-Ho Lee
Department of Pediatrics, College of Medicine, Chungnam National University, Taejeon, Korea
인간의 B세포 증식과 분화에 작용하는 인자들에 대한 연구
이광주, 정용헌, 이재호
충남대학교 의과대학 소아과학교실
We have studied the function of lymphokines on human tonsillar B cell proliferation and differentiation. B cells were stimulated with Staphylococcus aureus Cowan1(SAC) or anti-μ bead. The followings showed the results of this study. 1) In B cell activation, SAC induced B cell DNA synthesis but anti-μ bead did not. SAC could activate and proliferate B cells. Minimal number of B cells were required to proliferate effectively. 2) In B cell proliferation, SAC could proliferate B cell in the abscence of lymphokines. Exogenous IL-2 or IL-4 enhance B cell proliferation. The roles of IL-2 were very important in B cell proliferation. The effect of IL-4 on the IL-2 induced B cell proliferation was inhibitory in SAC-B cells IL-4 could enhance the proliferation of anti-μ bead activated B cells. 3) In B cell differentiation, IL-2 was a major factor to differentiate SAC activated B cells, but IL-4 did not. IL-6 had a synergistic effect on the differentiation. The results of this study showed that the different signal transduction mechanisms were involved in B cell proliferation and differentiation. The B cell resposes to lymphokine were different, and it is depend upon antigens or mitogens.
Key Words: B cell, Proliferation, Differentiation, BCGF , BCDF

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