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Effect of IVIG Treatment on Renal Function in Neonates

Journal of the Korean Pediatric Society 1994;37(10):1414-1419.
Published online October 15, 1994.
Effect of IVIG Treatment on Renal Function in Neonates
So Yeon Kim, Haeng Mi Kim
Department of Pediatrics, College of Medicine, Taegu, Korea
정주영 면역글로불린 투여가 신생아 신기능에 미치는 영향
김소연, 김행미
경북대학교 의과대학 소아과학교실
Abstract
This study was conducted to evaluate the effect of intraveneous immunoglobulin(IVIG) infusion on renal function in neonates. IVIG has provided quite safe in neonates given therapeutic doses. But nephrotoxicity is not a recognized adverse events of IVIG therapy, only several previous adult cases having been described. A total twenty five neonates suspected sepsis was randomely assigned to IVIG(n=12) or control(n=13) group. Neonates assigned to IVIG group received IVIG(1g/kg, 1dose) adjunct to ampicillin and gentamicin, and neonates assigned to control group received same antibiotics. To observe changes in renal function with IVIG therapy, serum BUN, creatinine, urine creatinine, β2-microglobulin(β2MG) and N-acetyl-β-D-glucosam-inidase(NAG) were obtained before and 24 hours, 3 and 7 days after initiation of therapy. There were no statistically sigmificant changes in serum BUN and creatinine in both groups. Transient increase of urine NAG was observed at 24 hous after therapy in IVIG group. Urine β2MG of IVIG group remained in pretreatment level, whereas decreased with age in control group, so, at 7th day IVIG group have higher urinary excretion of β2MG compared to control group. According to these results, it was found that IVIG therapy in neonates might cause transient renal tubular damage.
Key Words: Newborn, Intravenous immunoglobulin (IVIG), β2-microglobulin, NAG


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