| Comparison of Therapeutic Result of Oral Corticosteroid Versus Intravenous Gammaglobulin in Childhood Acute ITP |
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Jong-Hwan Kim, Hae-Won Kim, Hong-Ja Kang, Woo-Sik Chung, Kil Seo Kim |
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Department of Pediatrics, Dae Dong Hospital, Busan, Korea |
| 소아특발성 혈소판 감소성 자반증에서 스테로이드 및 정주용 감마글로불린 치료효과의 비교 |
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김종환, 김해원, 강홍자, 정우식, 김길서 |
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부산 대동병원 소아과 |
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| Abstract |
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A clinical study was conducted to compare effectiveness of IV Globulin with that of steriod in childhood acute ITP.
We carried out an experiment to 36 patients of acute ITP who recovered over 50,000/mm3 of platelet count and not to recur in 6 months.
Study group consist of 10 children who were treated with steriod only (Group A), 13 children who were treated with IV Globulin (0.4g/kg/d, 5 days, Group B), and 13 children combined with steroid(Group C).
Study period was from January 1988 to December 1992, following results were obtained.
1) There were no significant difference in sex ratio, age distribution, pretreatment hemoglobin level, platelet count and prolonged bleeding time among study groups.
2) The days which platelet count reached to 50,000/mm3, 100,000/mm3, 150,000/mm3 were 3.7 days (Group A), 2.1 days(Group B), and 2.3 days(Group C), respectively(p<0.05).
3) Complete response rates within 4 weeks did not show significant difference (90% in Group A, 84. 6% in Group B, 92.3% in Group C), the complete response rate within 1 week were significantly different among three group (44.4% in Group A, 90.9% n Group B, 83.3% in Group C)(p<0.05).
In conclusion, it is more desirable for early treatment of a childhood ITP because IV Globulin is easy to normalize platelet count in a short time. |
| Key Words:
ITP, Intravenous gamma globulin, Steriod |
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