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A Study of Relation between Serum Aminotransferase Elevation and Clinical Symptoms from Human Rotavirus Gastroenteritis

Journal of the Korean Pediatric Society 1995;38(1):54-60.
Published online January 15, 1995.
A Study of Relation between Serum Aminotransferase Elevation and Clinical Symptoms from Human Rotavirus Gastroenteritis
Gee Sun Hong, Hwa Young Jeon, Won Kyu Choi, Mee Kyung Namgoong, Jong Soo Kim
Department of Pediatrics, Yonsei University, Wonju College of Medicine, Wonju, Korea
Human Rotaviruw 위장염 환아에서 임상적 중등도와 혈청 Aminotransferase와의 관계
홍지선, 전화영, 최원규, 남궁미경, 김종수
연세대학교 원주의과대학 소아과학교실
Abstract
This study was taken to measure the serum aminotransferase level and it's correlation with clinical symptoms from Human Rotavirus gastroenteritis. This report is based on analysis of 434 patients who were admitted to the Pediatric department at Wonju Christian Hospital because of watery diarrhea and vomiting during 2-year period from July, 1991 to June 1993. The stool specimen on admission was tested for Rotavirus Ag by Rotazyme test. And then serum aminotransferase were checked. The result are as follows: 1) Rotavirus Antigens were detected in 194 cases (44.7%) among total 434 patients with gastroenteritis 2) The number of patients with AST elevation above the normal value in RTZ+group was 126 cases(64.9%) and, in RTZ-group was 65 cases(27.0%). 3) The mean value of AST in RTZ+ group was 41.7U/L and, in RTZ-group was 31.1U/L. The mean value of AST between the two groups were significantly different. 4) The mean value of ALT and GGT in the two groups were not different. 5) The patients with AST elevation above normal level in the RTZ+group was significantly increased in frequency and duration of diarrhea than RTZ+ group with normal AST level.
Key Words: Human Rotavirus(HRV), Serum aminotransferase


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