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Recurrent Hematuria due to Renal Hypouricemia

Journal of the Korean Pediatric Society 1995;38(1):129-132.
Published online January 15, 1995.
Recurrent Hematuria due to Renal Hypouricemia
Kyu Young Kim, Il Soo Ha, Hae Il Cheong, Yong Choi
Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea
반복적 혈뇨를 동반한 신성 저뇨산혈증 1례
김규영, 하일수, 정해일, 최용
서울대학교 의과대학 소아과학교실
A marked low concentration of serum uric acid(0.7-1.2mg/dl) was detected in a 14-year-old boy with recurrent episodes of gross hematuria. The hypouricemia accompanied with a markedly increased urinary clearance of uric acid (32.6-56.0ml/min), which was only minimally changed after both the administration of pyrazinamide, and inhibitor of the renal tubular secretion of uric acid, and the administration of probenecid, and inhibitor of the renal tubular reabsorption of uric acid. Other renal tubular functions were normal. There were no other family members with hypouricemia. Thies is the first case report of isolated renal hypouricemia due to presecretory reabsorption defect of uric acid in the renal proximal tubule in Korea. And renal hypouricemia should be included in the diagnosis of hematuria.
Key Words: Renal hypouricemia, Presecretory defect, Pyrazinamide suppression test, Probenecid suppression test

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